Proton beam therapy for pediatric ependymoma

Pediatrics International : Official Journal of the Japan Pediatric Society
Masashi MizumotoHideyuki Sakurai

Abstract

The aim of this study was to evaluate the efficacy of proton beam therapy for pediatric patients with ependymoma. Proton beam therapy was conducted for six patients (three boys and three girls; age, 2-6 years; median, 5 years) with ependymoma. The tumors were WHO grades 2 and 3 in two and four patients, respectively. All patients underwent surgery (subtotal and gross total resection in three patients each) and proton beam therapy at doses of 50.4-61.2 GyE (median, 56.7 GyE). The mean doses to normal brain tissue in proton beam therapy and photon radiotherapy were simulated using the same treatment planning computed tomography images. All patients completed the planned irradiation. The follow-up period was 13-44 months (median, 24.5 months) from completion of proton beam therapy and all patients were alive at the end of this period. Local recurrence in the treatment field occurred in one patient at 4 months after proton beam therapy at 50.4 GyE. Alopecia and mild dermatitis occurred in all patients, but there was no severe toxicity. One patient had a once-off seizure after proton beam therapy and alopecia persisted in another patient for 31 months, but no patients had difficulty with daily life. The simulation showed that proton...Continue Reading

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Citations

Jul 6, 2015·Current Treatment Options in Oncology·Rupa G JuthaniMichael A Vogelbaum
May 16, 2017·Pediatrics International : Official Journal of the Japan Pediatric Society·Hiroko FukushimaRyo Sumazaki
Sep 19, 2019·The British Journal of Radiology·Heike Thomas, Beate Timmermann
Jun 17, 2016·Journal of Neuro-oncology·James E BatesMichael T Milano
May 9, 2019·The British Journal of Radiology·Damien C WeberAlessia Pica
Feb 24, 2017·Radiation Oncology·Daichi TakizawaHideyuki Sakurai
Aug 24, 2016·The British Journal of Radiology·Fatima TensaoutiUNKNOWN radiotherapy committee of the French Society for Childhood Cancer (SFCE)
Jun 13, 2017·Neurologia Medico-chirurgica·Masashi MizumotoHideyuki Sakurai
Jan 29, 2020·Cancer Metastasis Reviews·Christina ColemanSabine Mueller
Sep 11, 2018·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Tomohei NakaoHideyuki Sakurai
Apr 4, 2021·International Journal of Radiation Oncology, Biology, Physics·Anita MahajanMichele Avanzo
May 14, 2021·Cancer Treatment Reviews·Masashi MizumotoHideyuki Sakurai

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