Proton-coupled electron hopping in Ru-modified P. aeruginosa azurin

Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry
Jeffrey J WarrenHarry B Gray

Abstract

We constructed two artificial multiple-step electron transfer (hopping) systems based on Pseudomonas aeruginosa azurin where a tyrosine (YOH) is situated between Ru(2,2'-bipyridine)2(imidazole)(histidine) and the native copper site: RuH107YOH109 and RuH124-YOH122. We investigated the rates of Cu(I) oxidation by flash-quench generated Ru(III) over a range of conditions that probed the role of proton-coupled oxidation/reduction of YOH in the reaction. Rates of Cu(I) oxidation were enhanced over single-step electron transfer by factors between 3 and 80, depending on specific scaffold and buffer conditions.

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Citations

Jul 28, 2017·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Martin WazlawikArne Dekker
Dec 14, 2018·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Taylor DevlinLaura M Hunsicker-Wang
Jun 9, 2020·Journal of the American Chemical Society·Brian KoronkiewiczJames M Mayer

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