Proton diffusion across membranes of vesicles of poly(styrene-b-acrylic acid) diblock copolymers

Journal of the American Chemical Society
Jun Wu, Adi Eisenberg

Abstract

A study of proton diffusion across membranes of block copolymer vesicles in dilute solution is described. The vesicles were formed by the self-assembly of a diblock copolymer of poly(styrene-b-acrylic acid) (PS(310)-b-PAA(36), where the numbers represent the degree of polymerization for individual blocks). A pH gradient was created across the vesicle membrane with the interior pH (pH(in)) of ca. 2.9 and the exterior pH (pH(out)) of ca. 8.5. The permeability of the polystyrene (PS) membrane was tuned by the addition of different amounts of dioxane (0-40 wt %) to the external aqueous solution. Proton concentrations in the solution outside of the vesicles were followed by monitoring the spectrum of a pH-sensitive fluorescent dye, namely 8-hydroxypyrene-1,3,6-trisulfonate. After the start of the experiment, the proton concentrations increase linearly with the square root of time, while the slopes of the lines increase with dioxane content. To calculate the diffusion coefficients of the protons across the vesicular membrane, the concentration data were fitted using a model, which describes the diffusion of species across the membrane of a reservoir. The apparent diffusion coefficient (D*, which equals the true diffusion coefficient ...Continue Reading

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Citations

Jul 9, 2010·Journal of the American Chemical Society·Yiyong Mai, Adi Eisenberg
Oct 3, 2009·Journal of the American Chemical Society·Dipanjan PanGregory M Lanza
Mar 25, 2009·ACS Nano·Guorong SunKaren L Wooley
Feb 16, 2012·Physical Chemistry Chemical Physics : PCCP·Liping WenLei Jiang
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Jan 1, 2012·Progress in Polymer Science·Daniel J SiegwartKrzysztof Matyjaszewski
Nov 21, 2015·The Journal of Physical Chemistry. B·Soonyong SoTimothy P Lodge
Aug 29, 2013·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Dipanjan PanGregory M Lanza
Oct 26, 2011·Contrast Media & Molecular Imaging·Dipanjan PanGregory M Lanza
May 16, 2017·Chemical Communications : Chem Comm·Zhen LiuChengxi Cao
Jan 16, 2018·Advanced Healthcare Materials·Jiayu LeongHyunjoon Kong
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Jul 14, 2018·Environmental Science & Technology·Patrick J GrayTimothy V Duncan
May 3, 2014·Journal of the American Chemical Society·Guhuan LiuShiyong Liu

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