Proton-enabled activation of peptide materials for biological bimodal memory

Nature Communications
Min-Kyu SongJang-Yeon Kwon

Abstract

The process of memory and learning in biological systems is multimodal, as several kinds of input signals cooperatively determine the weight of information transfer and storage. This study describes a peptide-based platform of materials and devices that can control the coupled conduction of protons and electrons and thus create distinct regions of synapse-like performance depending on the proton activity. We utilized tyrosine-rich peptide-based films and generalized our principles by demonstrating both memristor and synaptic devices. Interestingly, even memristive behavior can be controlled by both voltage and humidity inputs, learning and forgetting process in the device can be initiated and terminated by protons alone in peptide films. We believe that this work can help to understand the mechanism of biological memory and lay a foundation to realize a brain-like device based on ions and electrons.

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Citations

Sep 22, 2021·Angewandte Chemie·Jing ZhangHui Xu

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Methods Mentioned

BETA
NMR
Circular dichroism
transmission electron microscopy

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