PMID: 9537401Apr 16, 1998Paper

Proton gradient-driven nickel uptake by vacuolar membrane vesicles of Saccharomyces cerevisiae

Journal of Bacteriology
K NishimuraY Kakinuma

Abstract

A vacuolar H+-ATPase-negative mutant of Saccharomyces cerevisiae was highly sensitive to nickel ion. Accumulation of nickel ion in the cells of this mutant of less than 60% of the value for the parent strain arrested growth, suggesting a role for this ATPase in sequestering nickel ion into vacuoles. An artificially imposed pH gradient (interior acid) induced transient nickel ion uptake by vacuolar membrane vesicles, which was inhibited by collapse of the pH difference but not of the membrane potential. Nickel ion transport into vacuoles in a pH gradient-dependent manner is thus important for its detoxification in yeast.

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Citations

Mar 21, 2001·Biotechnology & Genetic Engineering Reviews·M W Persans, D E Salt
Oct 3, 2001·The Journal of Biological Chemistry·J P WeiE B Gralla
Sep 22, 2009·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Mustapha AouidaDindial Ramotar
Jan 8, 2011·Metallomics : Integrated Biometal Science·Mark R BleackleyRoss T A MacGillivray
Aug 9, 2001·Proceedings of the National Academy of Sciences of the United States of America·G BorrellyR Gibrat
Dec 30, 2008·Journal of Industrial Microbiology & Biotechnology·Yuan LiNorio Sugiura
Sep 18, 2014·Bioscience, Biotechnology, and Biochemistry·Takayuki SekitoYoshimi Kakinuma
Dec 2, 2004·The Journal of Biological Chemistry·Masamitsu ShimazuYoshimi Kakinuma
Apr 12, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Mark R Bleackley, Ross T A Macgillivray
Sep 3, 2013·FEMS Yeast Research·Gökhan KüçükgözeZ Petek Çakar
Dec 9, 2010·Molecular Plant-microbe Interactions : MPMI·Xiaopeng QiC Cheng Kao
Oct 27, 2017·FEMS Microbiology Reviews·Franziska GerwienSascha Brunke
Sep 21, 2018·Frontiers in Microbiology·Nicolas GrosjeanDamien Blaudez
Jun 19, 2019·Metallomics : Integrated Biometal Science·Trang Q NguyenPaul A Lindahl
Apr 20, 1999·Biochemical and Biophysical Research Communications·K NishimuraY Kakinuma
Mar 23, 2011·Biochimica Et Biophysica Acta·Rick OrijGertien J Smits

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