PMID: 7546005May 1, 1995Paper

Proton magnetic resonance spectroscopy in children with acute central nervous system injury

Pediatric Neurology
K L AuldD B Hinshaw

Abstract

Single voxel proton magnetic resonance spectroscopy (1H-MRS) was used in 30 infants and children with acute central nervous system injuries to determine the value of changes in specific metabolite ratios in predicting outcome. The mean age of all patients was 38 +/- 52 months and the mean time of study after insult was 7 +/- 5 days. 1H-MRS was determined in the occipital gray and parietal white matter (8 cm3 volume, STEAM sequence with TE = 20 ms, TR = 3,000 ms). Data were expressed as ratios of different metabolite peak areas including N-acetylaspartate (NA), choline-containing compounds (Ch), creatine and phosphocreatine (Cr), and lactate (Lac). Statistically significant differences were observed when patients with good/moderate (G/M) outcomes (n = 17; mean age: 46 months) were compared to patients with bad outcomes (n = 10; mean age: 26 months). NA/Cr and NA/Ch were significantly lower in the bad outcome group (NA/Cr = 1.15 +/- 0.38; NA/Ch = 1.18 +/- 0.52) compared to the G/M group (NA/Cr = 1.41 +/- 0.28, P < .05; NA/Ch = 1.98 +/- 0.81, P < .01). Lactate was present in 80% of bad outcome patients and in none of the G/M group (P < .0001). Using a linear discriminant analysis and combining 4 clinical variables (Glasgow Coma Sc...Continue Reading

References

Mar 1, 1975·Lancet·B Jennett, M Bond
Jul 1, 1992·Neurology·C C FordG A Rosenberg
Aug 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D Sappey-MarinierM W Weiner
Mar 1, 1992·Stroke; a Journal of Cerebral Circulation·G D GrahamJ W Prichard
Mar 1, 1992·European Journal of Radiology·B RossT Ernst
Jun 1, 1992·Radiology·J H DuijnM W Weiner
May 1, 1992·Journal of Computer Assisted Tomography·H BruhnJ Frahm
Aug 1, 1992·Stroke; a Journal of Cerebral Circulation·S R FelberF Gerstenbrand
Jan 1, 1991·Stroke; a Journal of Cerebral Circulation·G A RosenbergR H Griffey
Jun 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S J AustinE M Brett
Jul 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·D Bates
Sep 1, 1991·Clinics in Perinatology·P L Hope, J Moorcraft
Sep 1, 1990·Investigative Radiology·M J Fenstermacher, P A Narayana
Nov 1, 1990·Journal of Computer Assisted Tomography·C J PedenL M Dubowitz
Jan 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H BruhnR Sauter
Jul 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J FrahmR Sauter
May 26, 1994·The New England Journal of Medicine·UNKNOWN Multi-Society Task Force on PVS
Jan 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K JohannikA L Baert
Mar 1, 1994·Annals of Neurology·R SchiffmannC R Kaneski
Jun 2, 1994·The New England Journal of Medicine·UNKNOWN Multi-Society Task Force on PVS
Oct 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R KreisB D Ross
Jan 1, 1993·Pediatric Neurology·S Confort-GounyP J Cozzone
Jan 1, 1993·Journal of Inherited Metabolic Disease·J H CrossJ V Leonard

❮ Previous
Next ❯

Citations

Dec 16, 1998·Journal of Magnetic Resonance Imaging : JMRI·K H TaberL Maturi
Apr 18, 2003·Pediatric Neurology·Tamara BrennerStephen Ashwal
Jan 22, 1998·Pediatric Neurology·S K ShuD B Hinshaw
Nov 25, 2003·Academic Radiology·K Borowska-MatwiejczukB Kubas
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·L L ChengR G González
Jun 14, 2003·Current Opinion in Pediatrics·Hubert K TrübelGeorge Lister
Aug 10, 2013·Neuroimaging Clinics of North America·Lara A Brandão, Cristiana Caires
May 9, 2006·International Journal for Parasitology·Nicholas H HuntHelen J Ball
Jun 1, 2004·The Oncologist·Katherine E Warren
Feb 17, 2000·Journal of Magnetic Resonance Imaging : JMRI·B A HolshouserD B Hinshaw

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.