Proton magnetic resonance spectroscopy of mesial temporal sclerosis: Analysis of voxel shape and position to improve diagnostic accuracy

Journal of Computer Assisted Tomography
Steven G Imbesi

Abstract

To determine if change in voxel shape and position improves the lateralization of magnetic resonance (MR) spectroscopy to the side of the MR imaging and/or electroencephalography (EEG) abnormality in mesial temporal sclerosis. In 10 patients with unilateral mesial temporal sclerosis and 5 controls, MR spectroscopy was performed. Long echo time single-voxel spectroscopy was obtained in the right and left hippocampus. First, the standard 2-cm x 2-cm x 2-cm cubic voxels were placed bilaterally. Then, 1-cm x 2-cm x 4-cm rectangular voxels were used. With this rectangular voxel shape, more of the hippocampus and less of the adjacent medial temporal lobe were included in the interrogation voxel. N-acetylaspartate-to-creatine (NAA/Cr) ratios and choline-to-creatine (Cho/Cr) ratios were obtained. The difference between the affected and unaffected sides in the patients was calculated and compared with the controls. Additionally, the mean difference and standard deviation were determined. Predictive values and Student t tests were also performed. In all 10 patients, using the NAA/Cr ratios, the rectangular voxel correctly identified the abnormal side. The cubic voxel only identified the abnormal side in 6 of the 10 patients, however. Add...Continue Reading

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Citations

Jun 11, 2009·AJNR. American Journal of Neuroradiology·M E AhmadiE Halgren
Apr 15, 2021·Neuroradiology·Nadín Fernández-VegaNatalia García-Casares
Jun 10, 2008·Journal of Neuroradiology. Journal De Neuroradiologie·P Jissendi Tchofo, D Balériaux

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