Proton magnetic resonance spectroscopy of normal appearing white matter in asymptomatic relatives of multiple sclerosis patients

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
M Siger-Zajdel, K Selmaj

Abstract

Proton magnetic resonance spectroscopy of normal appearing white matter (NAWM) was performed in 25 first-degree relatives of patients with multiple sclerosis (MS). In relatives of MS patients, insignificant trends in the NAA/Cho ratio (to be lower) and in the Cho/Cr ratio (to be higher) were found when compared with healthy controls. These results demonstrated that there are only minimal, insignificant changes in commonly identified metabolite concentrations in NAWM of relatives of MS patients when compared with healthy subjects.

References

May 1, 1989·Acta Neurologica Scandinavica·T Engell
Sep 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J F HiehleF Gonzalez-Scarano
Jun 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R E BrennerW I McDonald
Feb 22, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·M CercignaniM Filippi
Jun 21, 2001·Hormone Research·S Lucinei BalboP C de Freitas Mathias
Jan 24, 2002·Neurology·Malgorzata Siger-ZajdelKrzysztof Selmaj
Jul 18, 2002·Multiple Sclerosis : Clinical and Laboratory Research·P KapellerD H Miller

❮ Previous
Next ❯

Citations

Jan 17, 2009·AJNR. American Journal of Neuroradiology·K K OguzB Anlar
Dec 13, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Anita TipirneniRobert Zivadinov
Aug 12, 2009·Multiple Sclerosis : Clinical and Laboratory Research·A SivaO H Kantarci
Aug 5, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kedar R Mahajan, Daniel Ontaneda
May 17, 2011·Neurologia i neurochirurgia polska·Elżbieta Jurkiewicz, Katarzyna Kotulska
Sep 7, 2021·Frontiers in Neurology·Zeinab GharaylouAbdorreza Naser Moghadasi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.