Proton magnetic resonance spectroscopy of musculoskeletal lesions at 3 T with metabolite quantification

Clinical Imaging
Chan Wha LeeShigeru Ehara

Abstract

To evaluate whether proton MR spectroscopy (MRS) at 3 T with metabolite quantification is helpful for characterizing musculoskeletal lesions and to reveal whether the concentration of choline is correlated with the pathologic degree of malignancy. Three-tesla MR images and proton MRS data from 27 consecutive patients with surgically proven musculoskeletal lesions were retrospectively analyzed. We analyzed the presence of choline peaks of malignant tumors according to the degree of malignancies, and we compared them with those of benign lesions. The concentrations of choline calculated by means of the linear combination of model spectra were also compared with respect to the degree of malignancy in each group. The proton MRS had an overall sensitivity of 68.4%, specificity of 87.5%, positive predictive value of 92.3%, and negative predictive value of 53.8% for the detection of choline compounds. The positive detection rate for choline compounds in the primary malignancy group (53.8%) was lower than that of the metastasis group (100%). All false-negative results were shown in the Grade 1 primary malignancy group. There was no difference in the concentration of choline compounds with respect to the pathologic degree of differentia...Continue Reading

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Citations

Jun 5, 2013·The Indian Journal of Surgery·S V S DeoN K Shukla
Nov 30, 2013·AJNR. American Journal of Neuroradiology·L M FayadP B Barker
Mar 19, 2014·European Radiology·Pedro A Gondim TeixeiraJacques Felblinger
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Mar 17, 2017·AJR. American Journal of Roentgenology·Pedro Augusto Gondim TeixeiraGabriela Hossu
Feb 1, 2019·Journal of Magnetic Resonance Imaging : JMRI·Takeshi FukudaMark E Schweitzer
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Sep 30, 2020·Seminars in Musculoskeletal Radiology·B Matthew HoweDoris E Wenger
Feb 12, 2017·Skeletal Radiology·Ruchi S PatniNripen Gogoi

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