PMID: 12752484May 20, 2003Paper

Proton magnetic resonance spectroscopy study of soleus muscle in non-obese healthy and Type 2 diabetic Asian Northern Indian males: high intramyocellular lipid content correlates with excess body fat and abdominal obesity

Diabetic Medicine : a Journal of the British Diabetic Association
Anoop MisraR M Pandey

Abstract

Intramyocellular lipids (IMCL) appears to be important in the pathogenesis of insulin resistance. Correlation of IMCL content of soleus muscle with insulin sensitivity has been reported in the Caucasian population. In the present study, IMCL content was estimated in the soleus muscle of both non-obese healthy males and Type 2 diabetic males, and correlated with the anthropometric parameters, blood glucose, plasma lipids, and insulin resistance in Asian Indians from North India. Twenty males (Type 2 diabetes mellitus 10; healthy controls 10) with body mass index (BMI) <or= 25 kg/m2 were recruited in the study. In both healthy and diabetic groups, five subjects had percentage body fat (%BF) <or= 25, and other five subjects had percentage BF > 25. The following were assessed in all subjects: body composition, fasting blood glucose, lipid profile, insulin levels, insulin resistance by homeostasis model assessment, and proton magnetic resonance spectroscopy (1H MRS) study of the soleus muscle. IMCL content was approximately two times higher in Type 2 diabetic males compared with healthy males (P < 0.05). Amongst healthy males, IMCL content was significantly higher (P < 0.05) in subjects with percentage BF > 25 compared with subjects...Continue Reading

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Citations

Sep 1, 2007·Indian Journal of Clinical Biochemistry : IJCB·S K MathurPraveen Sharma
Jul 21, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A Misra, L Khurana
Nov 11, 2009·Metabolic Syndrome and Related Disorders·Anoop Misra, Lokesh Khurana
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