Proton MR spectroscopy and white matter hyperintensities in idiopathic normal pressure hydrocephalus and other dementias.

The British Journal of Radiology
O AlginM Parlak

Abstract

The differentiation of idiopathic normal-pressure hydrocephalus (INPH) from other types of dementia is a clinical challenge. The aim of this prospective study was to evaluate the role of proton MR spectroscopy (MRS) and white matter hyperintensities (WMH) in the diagnosis of INPH, predicting response to therapy and differentiating INPH from other dementias. The study included 18 patients with INPH (Group 1), 11 patients with other types of dementia (Group 2) and 20 control patients (Group 3). The value of WMH scores and MRS findings in diagnosis, evaluation of response to therapy and in the differentiation of INPH from other dementias was statistically evaluated. The level of statistical significance was set at p<0.05 (Kruskal-Wallis and Mann-Whitney U-test). In both Groups 1 and 2, N-acetylaspartate (NAA)/choline-NAA/creatine ratios were significantly less than in the control group (p<0.05). The WMH and MRS findings of Groups 1 and 2 demonstrated no statistically significant correlation (p>0.05). No correlation was found between the outcome of shunt operations and WMH and MRS findings (p>0.05). In conclusion, neither WMH nor MRS were useful in differentiating INPH from other types of dementia. WMH and MRS showed no additional ...Continue Reading

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Citations

Jan 24, 2012·AJNR. American Journal of Neuroradiology·O Algin, B Turkbey
Dec 3, 2015·Japanese Journal of Radiology·Yasuyuki YamashitaSatoru Takahashi
Jun 7, 2014·Insights Into Imaging·Merve Gulbiz Kartal, Oktay Algin
Feb 9, 2011·European Journal of Radiology·Oktay AlginBahattin Hakyemez
Jan 19, 2021·Neurologia Medico-chirurgica·Madoka NakajimaUNKNOWN research committee of idiopathic normal pressure hydrocephalus
Jul 20, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Dermot H MallonZarni Win

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