PMID: 8952349Jul 1, 1996Paper

Proton MR spectroscopy findings in herpes simplex encephalitis

Rinshō shinkeigaku = Clinical neurology
M HitosugiH Fujii

Abstract

Localized proton magnetic resonance spectroscopy (1H-MRS) was conducted in two patients with herpes simplex virus type I encephalitis (HSE). MR spectra of bilateral temporal lobes were acquired by the single voxel method using 1.5T unit. Peaks indicating N-acetyl aspartate (NAA), choline (Cho) and creatine including phosphocreatine (Cr) were identified and ratios of NAA/Cr and Cho/Cr were calculated. These ratios were compared with those of the contralateral side showing normal MRI findings and also with the control spectra obtained from normal volunteers. Three abnormal findings were observed in the spectra of the patients suffering from HSE; 1. significant reduction of the NAA/Cr ratio at the involved temporal lobe, 2. mild reduction of the NAA/Cr ratio at the normal temporal lobe, and 3. elevation of the Cho/Cr ratio at the bilateral lobes, but more significant on the involved sides. These results indicated that neural loss and gliosis occurred in the contralateral area with normal MR images as well as the involved hemisphere. We concluded that 1H-MRS is able to show the specific histological findings of herpes simplex encephalitis. This is the first report assessing 1H-MRS for patients with HSE in Japan.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.