Proton MR spectroscopy in normal breasts between pre- and postmenopausal women: a preliminary study

AJR. American Journal of Roentgenology
Jane WangTiffany Ting-Fang Shih

Abstract

The purpose of our study was to assess the differences in the water and lipid fractions and lipid line widths in normal breasts between premenopausal and postmenopausal women using single-voxel proton MR spectroscopy (1H-MRS). Thirty-two premenopausal and 25 postmenopausal women were enrolled in the study. Single-voxel proton MR spectroscopy of the breast was performed using point-resolved spectroscopy (PRESS) with water suppression and stimulated echo acquisition mode (STEAM). On STEAM, water fraction 1 was the ratio of the integration of water to the sum of the integration of water and methylene resonances, and the lipid fraction 1 was the ratio of the integration of methylene to water and methylene resonances. Lipid fraction 2 was the ratio of the integration of allylic methylene to water and allylic methylene resonances. Lipid line width was measured on PRESS. The premenopausal group had a higher water fraction 1 and lower lipid fraction 1 than the postmenopausal group (p < 0.01, Student's t test). The breast density had a positive effect on water fraction 1 and a negative effect on lipid fraction 1 for premenopausal women (p = 0.018, multivariate regression) and for the total population (p = 0.019). The premenopausal women...Continue Reading

References

Jan 1, 1989·AJR. American Journal of Roentgenology·D B Kopans, C A Swann
Nov 5, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S J GrahamM J Bronskill
Oct 14, 1998·Radiology·J R RoebuckR E Lenkinski
Dec 16, 1998·Journal of Magnetic Resonance Imaging : JMRI·I S GribbestadP A Rinck
May 29, 1999·Journal of Computer Assisted Tomography·J R ReichenbachW A Kaiser
Aug 10, 1999·Journal of Magnetic Resonance Imaging : JMRI·K A KvistadO Haraldseth

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