PMID: 6166942May 1, 1981Paper

Proton NMR studies of the Zn(II)--bleomycin-A2--poly(dA-dT) ternary complex

Proceedings of the National Academy of Sciences of the United States of America
J D GlicksonT T Sakai

Abstract

Proton NMR spectra demonstrate the formation of a ternary complex, Zn(II)--bleomycin-A2--poly(dA-dT), which serves as an analog of the putative active complex, Fe(II)--bleomycin-A2--DNA. Specific sites of metal--drug and drug--nucleic acid interaction have been delineated on the basis of chemical shift perturbations. On the basis of this criterion there appear to be three distinct regions of the drug: (i) the NH2 terminus up to and including the disaccharide and hydroxyhistidine residues, whose resonances are perturbed only by metal interactions; (ii) the COOH-terminal dipeptide, whose resonances are displaced only by nucleic acid interactions; and (iii) the methylvaleric acid-threonine dipeptide, which links these domains and whose resonances are sensitive to both types of interactions. The spectral perturbations in the first and second domains are very similar to changes observed in the corresponding binary complexes--i.e., Zn(II)--bleomycin-A2 and bleomycin-A2--poly(dA-dT), respectively.

References

Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·N J OppenheimerS M Hecht
Jan 15, 1980·Biochemical and Biophysical Research Communications·D M ChenD J Patel
Sep 16, 1980·Biochemical and Biophysical Research Communications·R P PillaiJ D Glickson
Nov 17, 1980·Biochemical and Biophysical Research Communications·R P PillaiJ D Glickson

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Citations

Jan 1, 1990·Chemico-biological Interactions·D H PeteringW E Antholine
Dec 1, 1983·Journal of Biomolecular Structure & Dynamics·T T SakaiA Levy
Oct 1, 1990·Journal of Biomolecular Structure & Dynamics·D WilliamsonJ D Glickson
Apr 1, 1990·Journal of Biomolecular Structure & Dynamics·M P GamcsikG Zon
Sep 25, 1985·Nucleic Acids Research·J P HénichartR Houssin
Jun 11, 1993·Nucleic Acids Research·K P Nightingale, K R Fox
Aug 7, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Teresa Lehmann, Elena Topchiy
Jan 1, 1983·Drug Metabolism Reviews·K E Mc LaneK Ramakrishnan
Apr 19, 1988·Biochemistry·M J Levy, S M Hecht

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