Proton nuclear magnetic resonance spectroscopy of urine samples in preterm asphyctic newborn: a metabolomic approach

Clinica Chimica Acta; International Journal of Clinical Chemistry
M LonginiG Buonocore

Abstract

In order to highlight differences in the metabolic profile of healthy (control) compared with asphyxiated newborns, by using untargeted metabolomic approach coupled with (1)H NMR spectroscopy, we evaluated the effects of asphyxia on newborn urine metabolites. Our results showed that lactate, glucose and TMAO, together with threonine plus 3-hydroxyisovalerate are the metabolites more characterizing the asphyxiated group; lower contribute to discrimination is related to other metabolites such as dimethylglycine, dimethylamine, creatine, succinate, formate, urea and aconitate. After 24-48h from resuscitation preterm asphyctic neonates showed their recovery pattern that still can be differentiated by the controls.

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Citations

Nov 14, 2015·Journal of Proteome Research·Sílvia O DiazAna M Gil
May 22, 2019·Applied Biochemistry and Biotechnology·Zuleen Delina Fasya Abdul GhaniZamri Chik
Apr 9, 2020·Metabolites·Emanuela LocciErnesto d'Aloja
Mar 29, 2020·Italian Journal of Pediatrics·Flaminia Bardanzellu, Vassilios Fanos
Jul 13, 2021·Frontiers in Pediatrics·Marie Julie DebufFiammetta Piersigilli
Aug 10, 2017·Journal of Proteome Research·Aurélien ScalabrePierre-Yves Mure

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