Proton pencil beam scanning for mediastinal lymphoma: the impact of interplay between target motion and beam scanning

Physics in Medicine and Biology
C ZengStefan Both

Abstract

The purpose of this study was to assess the feasibility of proton pencil beam scanning (PBS) for the treatment of mediastinal lymphoma. A group of 7 patients of varying tumor size (100-800 cc) were planned using a PBS anterior field. We investigated 17 fractions of 1.8 Gy(RBE) to deliver 30.6 Gy(RBE) to the internal target volume (ITV). Spots with σ ranging from 4 mm to 8 mm were used for all patients, while larger spots (σ = 6-16 mm) were employed for patients with motion perpendicular to the beam (⩾5 mm), based on initial 4-dimensional computed tomography (4D CT) motion evaluation. We considered volumetric repainting such that the same field would be delivered twice in each fraction. The ratio of extreme inhalation amplitude and regular tidal inhalation amplitude (free-breathing variability) was quantified as an indicator of potential irregular breathing during the scanning. Four-dimensional dose was calculated on the 4D CT scans based on the respiratory trace and beam delivery sequence, implemented by partitioning the spots into separate plans on each 4D CT phase. Four starting phases (end of inhalation, end of exhalation, middle of inhalation and middle of exhalation) were sampled for each painting and 4 energy switching ti...Continue Reading

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Citations

Feb 21, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jennifer VogelCharles B Simone
Mar 21, 2019·Physics in Medicine and Biology·G FattoriS Safai
Feb 26, 2019·International Journal of Particle Therapy·Andrew J BoriaChia-Ho Hua
Feb 6, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Cássia O RibeiroAntje Knopf
Aug 10, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Arturs MeijersStefan Both

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