PMID: 8963397Dec 1, 1995Paper

Proton-pump inhibition and gastric giardiasis: a causal or casual association?

Journal of Gastroenterology
H ReynaertG Devis

Abstract

Two patients who developed gastric giardiasis after 2 weeks of treatment with omeprazole 20 mg b.i.d. followed by omeprazole 20 mg per day for 2-6 weeks are described. In one patient, gastric giardiasis occurred in the presence of only mild intestinal metaplasia. In the other patient, Giardia lamblia infection had resolved 4 weeks after the cessation of omeprazole treatment, which, to our knowledge, is the first case reported in the literature. It is tempting to speculate that gastric giardiasis can develop in the absence of mucosal abnormalities during hypochlorhydria induced by treatment with a high dose of a proton-pump inhibitor. Specific treatment may not be required if the drug can be stopped and no other gastric disease causing hypochlorhydria is present.

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Citations

Mar 3, 2011·Digestive Diseases and Sciences·Edward Sheen, George Triadafilopoulos
Feb 11, 2004·The American Journal of the Medical Sciences·Sayed Saeid KhatamiKeyvan Ravakhah
Aug 22, 2000·Immunopharmacology and Immunotoxicology·G AgastyaJ M Callahan
Aug 19, 2007·Expert Opinion on Pharmacotherapy·Angel A Escobedo, Sergio Cimerman
Apr 1, 2017·Clinical Drug Investigation·Leon Fisher, Alexander Fisher
Dec 3, 2014·The Cochrane Database of Systematic Reviews·Huan SongDongHao Lu
Sep 17, 2014·Antimicrobial Agents and Chemotherapy·Horacio Reyes-VivasGabriel López-Velázquez
Dec 5, 2019·International Journal of Molecular Sciences·Tom C MartinsenHelge L Waldum
Aug 12, 2021·Clinical Microbiology Reviews·Rodney D Adam

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