Proton pump inhibition increases rapid eye movement sleep in the rat

BioMed Research International
Munazah Fazal Qureshi, Sushil K Jha


Increased bodily CO2 concentration alters cellular pH as well as sleep. The proton pump, which plays an important role in the homeostatic regulation of cellular pH, therefore, may modulate sleep. We investigated the effects of the proton pump inhibitor "lansoprazole" on sleep-wakefulness. Male Wistar rats were surgically prepared for chronic polysomnographic recordings. Two different doses of lansoprazole (low: 1 mg/kg; high: 10 mg/kg) were injected intraperitoneally in the same animal (n = 7) and sleep-wakefulness was recorded for 6 hrs. The changes in sleep-wakefulness were compared statistically. Percent REM sleep amount in the vehicle and lansoprazole low dose groups was 9.26 ± 1.03 and 9.09 ± 0.54, respectively, which increased significantly in the lansoprazole high dose group by 31.75% (from vehicle) and 34.21% (from low dose). Also, REM sleep episode numbers significantly increased in lansoprazole high dose group. Further, the sodium-hydrogen exchanger blocker "amiloride" (10 mg/kg; i.p.) (n = 5) did not alter sleep-wake architecture. Our results suggest that the proton pump plays an important role in REM sleep modulation and supports our view that REM sleep might act as a sentinel to help maintain normal CO2 level for u...Continue Reading


Jan 1, 1984·Sleep·S IoffeV Chernick
Mar 1, 1982·The American Journal of Physiology·D J Benos
Jan 1, 1996·Annual Review of Physiology·S L GluckB S Lee
Oct 16, 1999·Lancet·J G Laffey, B P Kavanagh
Apr 17, 2001·Antimicrobial Agents and Chemotherapy·R PiccolominiM Neri
Dec 12, 2001·Respiration Physiology·Jay B DeanRobert W Putnam
Jan 18, 2002·Journal of Applied Physiology·Richard L HornerSandeep Sood
Jul 1, 1958·The Journal of Clinical Investigation·E D ROBIND M TRAVIS
Aug 17, 2005·Sleep Medicine Reviews·Mark R Opp
Oct 13, 2006·American Journal of Physiology. Renal Physiology·Sylvie Breton, Dennis Brown
Jun 30, 2007·American Journal of Respiratory and Critical Care Medicine·Heidrun Kiwull-SchöneMartin Wiemann
Nov 26, 2008·Journal of Neural Transmission·Jarogniew J LuszczkiStanislaw J Czuczwar
Mar 6, 2009·The American Journal of Gastroenterology·Karl L Insogna
Aug 28, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Anna E KershRobert W Putnam
Jan 23, 2010·Journal of Applied Physiology·Daniel K MulkeyOrsolya Kréneisz
Dec 22, 2010·Neuron·Lucia Tabares, Bill Betz
Jan 24, 2013·Investigative Ophthalmology & Visual Science·Anne M HannekenWallace B Thoreson
Mar 23, 2013·PloS One·Nahuai BadiolaPatrick Aloy

Related Concepts

Proton Pump Inhibitors
Lansoprazole Sodium
Sodium-Hydrogen Antiporter
ATP12A gene
Metabolic Inhibition
Proton Pump
Sleep, REM
Proton Pump Activity
Regulation of Cellular pH

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.