Proton pump inhibitor alone vs proton pump inhibitor plus mucosal protective agents for endoscopic submucosal dissection-induced ulcer: a systematic review and meta-analysis

Journal of Clinical Biochemistry and Nutrition
Toshihiro NishizawaNaohisa Yahagi

Abstract

Mucosal protective agents may improve healing of patients with endoscopic submucosal dissection-induced ulcers. The present study systematically evaluated published clinical trials to determine whether combined therapeutic use of mucosal protective agents and proton pump inhibitors can improve the outcome of patients with endoscopic submucosal dissection-induced ulcers compared to treatment with proton pump inhibitors alone. PubMed, the Cochrane Library, and the Igaku-Chuo-Zasshi database were searched to identify eligible randomized trials for systematic review. We identified 11 randomized trials for inclusion in our study (1,160 patients). Pooled endoscopic submucosal dissection-induced ulcer healing rates were 45.8% and 34.4% for patients with or without mucosal protective agents, respectively. The odds ratio was 2.28 (95% confidence interval, 1.57-3.31) with no significant study heterogeneity. In conclusion, the systematic review and meta-analysis showed that the combined therapeutic use of proton pump inhibitors and mucosal protective agents improved healing rates of endoscopic submucosal dissection-induced ulcers compared to treatment with proton pump inhibitor monotherapy.

References

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Citations

Jun 28, 2016·Gastrointestinal Endoscopy·Diogo LibânioMário Dinis-Ribeiro
Jun 6, 2018·Journal of Gastroenterology and Hepatology·Rapat PittayanonAlan Barkun
Jan 27, 2018·Journal of Clinical Biochemistry and Nutrition·Akinori Yanaka
Feb 9, 2021·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Jong Yoon Lee, Jin Seok Jang
Mar 16, 2021·Terapevticheskiĭ arkhiv·D N Andreev, I V Maev
Nov 2, 2021·Experimental and Therapeutic Medicine·Mingru LiZhaoyang Liu

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Methods Mentioned

BETA
dissection

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