Proton pump inhibitor prescribing patterns in newborns and infants

The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG
Marta IlluecaHuiying Yang

Abstract

In 2011, the Food and Drug Administration (FDA) approved intravenous esomeprazole 0.5 mg/day for children aged >1 month and oral esomeprazole for infants aged 1 month to <1 year at doses of 2.5, 5, and 10 mg based on weight. Prior to 2011, proton pump inhibitors (PPIs) were not approved for use in infants aged <1 year. This study determined PPI usage rates prior to the FDA approval among newborns and infants in both the inpatient and outpatient settings and compared PPI and histamine-2 receptor antagonist (H2RA) usage in the inpatient setting. We conducted a retrospective analysis of PPI prescribing patterns for newborns and infants from 2003 to 2008 using data from the Premier Perspective Inpatient Hospital Database and the PharMetrics Patient-Centric Database for inpatient and outpatient data, respectively. PPI use and diagnoses were determined from clinical and charge records from more than 500 hospitals. Descriptive statistics were used to summarize the findings. Our analysis showed that PPIs were prescribed for approximately 5000 newborns (0.13%) and 15,000 infants (2.65%) each year in the hospital setting and 1.6% of newborns and infants, as a group, in the outpatient setting. Newborns and infants receiving PPIs most ofte...Continue Reading

References

Aug 30, 2001·Journal of Pediatric Gastroenterology and Nutrition·C D RudolphUNKNOWN North American Society for Pediatric Gastroenterology and Nutrition
Nov 22, 2007·Journal of Pediatric Gastroenterology and Nutrition·John J BarronJoseph Singer
Apr 9, 2009·The American Journal of Gastroenterology·Philip M ShermanYvan Vandenplas

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Citations

Nov 22, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Mark SafeUsha Krishnan
Nov 6, 2020·European Journal of Pediatrics·Elvira Ingrid LevyJ Peter de Winter
Jul 8, 2020·Expert Review of Gastroenterology & Hepatology·Abdelhalim Ouald ChaibYvan Vandenplas

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