Proton pump inhibitors and acute interstitial nephritis

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Nimeshan GeevasingaSimon D Roger

Abstract

Proton pump inhibitors (PPIs) are a widely prescribed class of drugs, and their usage worldwide is increasing. Although well-tolerated, there have been case reports and a recent case series implicating these drugs in acute interstitial nephritis (AIN) and progression to acute renal failure (ARF). The aim of this study was to investigate how widespread this complication is in Australia, to identify which PPIs are implicated, and to establish whether PPI-induced AIN is a class effect. We undertook a retrospective case review of potential cases at 2 teaching hospitals and a review of registry data from the Therapeutic Goods Administration of Australia (TGA). Parameters sought included the drug implicated, concurrent medications, symptoms, signs, serum creatinine, and time of onset after prescription. We identified 18 cases of biopsy-proven PPI-induced AIN causing ARF in the retrospective case review, which is the largest hospital-based case series to date. The TGA registry data identified an additional 31 cases of "biopsy proven interstitial nephritis." An additional 10 cases of "suspected interstitial nephritis," 20 cases of "unclassified acute renal failure," and 26 cases of "renal impairment" were also identified. All 5 commerc...Continue Reading

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Oct 1, 1992·The American Journal of Medicine·S J RuffenachY H Lien
Mar 1, 1991·Kidney International·C J KellyC M Meyers
Oct 1, 1994·Australian and New Zealand Journal of Medicine·C R LewisJ W Agar
Aug 1, 1993·The American Journal of Medicine·J J Kuiper
Jan 1, 1997·Renal Failure·G d'AdamoF Gangeri
Nov 14, 1997·Alimentary Pharmacology & Therapeutics·H LeufkensC B Lamers
Dec 12, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D BadovJ Dowling
Dec 31, 1997·Journal of Clinical Gastroenterology·D YipM Findlay
Jun 17, 1998·American Journal of Nephrology·J J Montseny, A Meyrier
Nov 4, 1998·Postgraduate Medical Journal·M J LandrayI R Arnold
Aug 5, 2000·The Netherlands Journal of Medicine·A T PostA L Zanen
Sep 9, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C A WallG J Mellotte
Oct 3, 2000·Nephron·M NakamuraK Hamaguchi
Nov 30, 2000·Nursing·J Shuster
Dec 9, 2000·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·D W Claussen
Dec 21, 2000·Journal of Clinical Pharmacy and Therapeutics·M NauntonM D Bleasel
Jan 27, 2004·The Annals of Pharmacotherapy·Amy Ra, Sheldon W Tobe
Mar 9, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nicholas TorpeyCalum Ross

❮ Previous
Next ❯

Citations

May 4, 2011·International Urology and Nephrology·Tolga YildirimCetin Turgan
Jul 16, 2008·Current Gastroenterology Reports·Gregory A Coté, Colin W Howden
Mar 16, 2007·Nature Clinical Practice. Gastroenterology & Hepatology·Viralkumar Patel, John S Fordtran
Jun 3, 2010·Nature Reviews. Nephrology·Mark A Perazella, Glen S Markowitz
Nov 3, 2010·Southern Medical Journal·Syed HussainMichael Rothberg
Oct 4, 2006·Nephrology·Simon D Roger
Jul 20, 2013·BMC Nephrology·Donald G KlepserGary L Cochran
Oct 31, 2012·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Sheila KlassenAlly P H Prebtani
Aug 21, 2013·Indian Journal of Nephrology·K SampathkumarA Abraham
Jun 15, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Angela K MuriithiSamih H Nasr
Jul 16, 2014·Clinics in Liver Disease·Marcelo S SampaioSuphamai Bunnapradist
Jan 5, 2016·European Journal of Internal Medicine·Ettore Bartoli
Jan 21, 2016·Neuropsychological Rehabilitation·Christodouli LagogianniNadina Lincoln
Dec 14, 2006·Kidney International·U C Brewster, M A Perazella
Sep 4, 2014·Kidney International·Angela K MuriithiSamih H Nasr
Apr 16, 2008·The American Journal of Emergency Medicine·Vikhyat S BebartaMarie McDonough
Apr 9, 2008·La Revue de médecine interne·C BaudeauN Patey-Mariaud de Serre
Aug 18, 2009·Journal of the American Geriatrics Society·Mahesh KrishnamurthyMarina Bachurina
Jun 27, 2009·Pharmacoepidemiology and Drug Safety·Jen-Tzer GauTzu-Cheg Kao
Jul 31, 2007·Alimentary Pharmacology & Therapeutics·F SierraM F Vela
Jan 9, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R MirakianUNKNOWN BSACI
Jul 20, 2007·British Journal of Clinical Pharmacology·Linda HärmarkA C van Grootheest
Jul 12, 2008·Alimentary Pharmacology & Therapeutics·E CoronUNKNOWN Consortium de Recherche Indépendant sur le Traitement et L'exploration du Reflux Gastro-oesophagien et de L'endobrachyoesoph
Dec 15, 2010·Journal of the American Geriatrics Society·Nina NiChandrika Kumar
May 25, 2010·Internal Medicine Journal·S V GadzhanovaJ M Mackson
Mar 19, 2014·Nephrology·Linda Berney-MeyerRobert J Walker
Oct 19, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Richard R Babb
Apr 14, 2016·Journal of Nephrology·Dennis G Moledina, Mark A Perazella
Apr 16, 2016·Journal of the American Society of Nephrology : JASN·Dennis G Moledina, Mark A Perazella
Apr 27, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Anushree C ShiraliScott Gettinger
Jun 21, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Vincenzo SavarinoEdoardo Savarino
Nov 14, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Scott J Duncan, Colin W Howden
May 1, 2009·Expert Review of Clinical Pharmacology·Alex Mejia, Walter K Kraft
Dec 14, 2016·Histopathology·Paisit Paueksakon, Agnes B Fogo
Sep 13, 2012·Surgical Innovation·Vinciane MulsGuido Costamagna
Nov 19, 2011·Digestive Diseases·Bojan Tepeš
Sep 21, 2017·Nature Reviews. Gastroenterology & Hepatology·Peter MalfertheinerMarino Venerito
Aug 26, 2014·British Journal of Hospital Medicine·Carina OwenMatthew Banks
Apr 19, 2018·Journal of Clinical Gastroenterology·Faisal KamalColin W Howden

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

© 2022 Meta ULC. All rights reserved