Proton pump inhibitors and adverse effects in kidney transplant recipients: A meta-analysis

World Journal of Transplantation
B BoonphengWisit Cheungpasitporn

Abstract

The adverse renal effects of proton pump inhibitors (PPIs) are increasingly recognized in both the general population and patients with chronic kidney disease. Several pharmacokinetic studies have also raised concerns regarding the interaction between PPIs and immunosuppressive drugs in transplant patients. Whether the adverse effects of PPIs have a clinical significance in kidney transplant recipients remains unclear. We performed this meta-analysis to assess the risk of adverse effects in kidney transplant recipients on PPI compared with those without PPI exposure. To investigate the risk of acute rejection, graft loss, hypomagnesemia, renal dysfunction, and overall mortality in kidney transplant recipients on PPI compared with those without PPI exposure. A systematic review was conducted in MEDLINE, EMBASE, and Cochrane databases from inception through October 2018 to identify studies that evaluated the adverse effects of PPIs in kidney transplant recipients, including biopsy-proven acute rejection, graft loss, hypomagnesemia, renal function, and overall mortality. Effect estimates from the individual studies were extracted and combined using random-effect, generic inverse variance method of DerSimonian and Laird. The protoc...Continue Reading

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Citations

Jan 23, 2020·Journal of Clinical Medicine·Dominik J G FlothowStefan Reuter
Apr 26, 2020·Journal of Clinical Medicine·Charat ThongprayoonWisit Cheungpasitporn
Dec 11, 2019·Journal of Clinical Medicine·Rianne M DouwesStephan J L Bakker
Oct 11, 2020·Pharmacotherapy·Spenser E JanuaryAndrew F Malone

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Software Mentioned

PROSPERO
Comprehensive Meta - analysis

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