PMID: 25743791Mar 7, 2015Paper

Proton pump inhibitors and helicobacter pylori-associated pathogenesis

Asian Pacific Journal of Cancer Prevention : APJCP
Tadashi HagiwaraHiroyuki Sugihara

Abstract

The fact that long-term use of proton pump inhibitors (PPIs) aggravates corpus atrophic gastritis in patients with Helicobacter pylori infection has been proven clinically and experimentally. Corpus atrophic gastritis is a known risk factor for gastric cancer. Therefore, gastric neoplasia might be associated with the long-term use of PPIs. One of the causes of worsening corpus atrophic gastritis, leading to the development of adenocarcinoma, might be bacterial overgrowth under conditions of hypochlorhydria. The production of potentially carcinogenic N-nitrosocompounds by nitrosating organisms under conditions of hypochlorhydria might be associated with carcinogenesis. Interactions between bile acids, pH, and H. pylori might also contribute to carcinogenicity, especially in patients with gastro-esophageal reflux disease (GERD). The concentration of soluble bile acids, which have bactericidal or chemorepellent properties toward H. pylori, in gastric contents is considerably higher in patients undergoing continuous PPI therapy than in healthy individuals with normal acid production. Under these circumstances, H. pylori might colonize the stomach body rather than the pyloric antrum. Hypergastrinemia induced by PPI administration mi...Continue Reading

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Citations

Apr 27, 2019·Frontiers in Pharmacology·Amin Talebi Bezmin Abadi, Enzo Ierardi
Feb 26, 2016·World Journal of Gastrointestinal Pathophysiology·Rong-Guang ZhangShuai-Yin Chen
Jan 23, 2016·World Journal of Clinical Cases·Maliheh SafaviAlireza Foroumadi
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Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sherif A Abdel-GawadAlhumaidi B Alabbas

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Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.