Proton Pump Inhibitors in Children: the Good, the Bad, and the Ugly.

Current Allergy and Asthma Reports
Eric A PasmanCade M Nylund

Abstract

The evidence supporting or contesting the prescription of proton pump inhibitors (PPIs) for children and updates on side effects are reviewed. PPIs remain an important therapeutic option for esophagitis and gastritis. However, recent studies demonstrate no benefit when prescribing PPIs for chronic cough, infantile reflux, asthma, or functional gastrointestinal disorders. Recent studies suggest adverse effects on microbiome diversity and immune function, resulting in increased rates of gastrointestinal infections, bone fractures, and atopic disorders. PPIs influence a variety of cell types within the in the innate and adaptive immune systems. PPI prescriptions in children may be indicated for select conditions; however, multiple side effects and immune effects have been described. While most of these side effects are rare and mild, some studies suggest enduring adverse effects. Future studies to elucidate the mechanism behind some of these immune and infectious complications will be beneficial.

References

May 13, 1999·Immunopharmacology and Immunotoxicology·E CapodicasaM A Pelli
May 15, 2002·Critical Care Medicine·Konstantin Zedtwitz-LiebensteinWolfgang Graninger
Jan 27, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eva UntersmayrErika Jensen-Jarolim
May 3, 2006·Pediatrics·Roberto Berni CananiUNKNOWN Working Group on Intestinal Infections of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGEN
Aug 26, 2006·Pediatric Surgery International·Akinari HinokiAkira Satomi
Jun 29, 2007·Digestive Diseases and Sciences·Huseyin AlkimTurgut Imir
Nov 21, 2007·Infection and Immunity·Sharon M TennantIan R van Driel
Nov 22, 2007·Journal of Pediatric Gastroenterology and Nutrition·John J BarronJoseph Singer
Dec 7, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Luis Alberto García RodríguezJulián Panés
Jan 19, 2008·BMJ : British Medical Journal·Jecko Thachil
Mar 14, 2008·International Journal of Immunopathology and Pharmacology·E CapodicasaL Scaringi
Aug 29, 2009·Digestive Diseases and Sciences·Ramalinga R KedikaStuart Jon Spechler
Dec 17, 2009·Digestive Diseases and Sciences·Masaki SanakaYasushi Kuyama
Dec 17, 2009·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Tsuneyuki UbagaiYasuo Ono
Apr 12, 2011·The Journal of Allergy and Clinical Immunology·Chris A LiacourasSeema S Aceves
Jun 21, 2011·Clinical Pediatrics·Jose M GarzaAjay Kaul
Oct 18, 2011·Alimentary Pharmacology & Therapeutics·C Bavishi, H L Dupont
Jan 26, 2012·JAMA : the Journal of the American Medical Association·UNKNOWN Writing Committee for the American Lung Association Asthma Clinical Research CentersW Gerald Teague
Mar 27, 2012·Alimentary Pharmacology & Therapeutics·A B T AndersenH T Sørensen
Mar 13, 2013·Journal of Gastroenterology·Wensheng LiuLixin Zhu
Oct 30, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B MulderE Hak
Nov 26, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Sumit BoseAleena Banerji
Jan 28, 2014·Journal of Pediatric Gastroenterology and Nutrition·Pauline De BruyneMyriam Van Winckel
Mar 19, 2014·Nephrology·Linda Berney-MeyerRobert J Walker
Jun 20, 2014·Immunological Reviews·Lucia M KatoSidonia Fagarasan
Jul 6, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Evan S DellonNicholas J Shaheen
Sep 13, 2014·The ISME Journal·Husen ZhangXin M Luo
Mar 11, 2015·British Journal of Clinical Pharmacology·Shlomi CohenFrancis B Mimouni
May 20, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D E FreedbergY-X Yang
Jun 23, 2015·Journal of Clinical Pharmacology·Maayan Yitshak-SadeLena Novack
Aug 8, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Alfredo J LucendoJavier Molina-Infante
Sep 28, 2015·The Journal of Pediatrics·Christopher M Stark, Cade M Nylund
Nov 28, 2015·Alimentary Pharmacology & Therapeutics·L Cea SorianoL A García-Rodríguez
Dec 15, 2015·Gut·Floris ImhannAlexandra Zhernakova
Jan 26, 2016·The Journal of Allergy and Clinical Immunology. in Practice·Inês MotaMário Morais-Almeida
Jan 27, 2016·Current Allergy and Asthma Reports·Iris M Otani, Aleena Banerji
Jun 17, 2016·Science Translational Medicine·Nicholas A BokulichMartin J Blaser
Aug 2, 2016·Journal of Clinical Gastroenterology·Steve B MinFouad J Moawad

❮ Previous
Next ❯

Citations

Sep 14, 2021·Acta Paediatrica·Noora HelinLaura Merras-Salmio

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Revue médicale suisse
Massimo MaffeiAntoine Hadengue
Journal of Neurogastroenterology and Motility
Yoshikazu KinoshitaShunji Ishihara
Expert Opinion on Drug Safety
Laura E Targownik, William D Leslie
© 2022 Meta ULC. All rights reserved