Proton pump inhibitors (PPIs) may cause gastric cancer - clinical consequences

Scandinavian Journal of Gastroenterology
Helge L WaldumR Fossmark

Abstract

Recently, two epidemiological studies showed that long-term treatment with proton pump inhibitors (PPIs) increased the risk of gastric cancer. It is well known that hypergastrinemia predisposes to gastric neoplasia in animals as well as man. Recently a study showed that hypergastrinemic patients had an increased risk of gastric cancer when followed for about 25 years. It is likely that hypergastrinemia is the pathogenic factor for gastric carcinogenesis due to PPI. PPI are the only group of drugs that causes long-term hypergastrinemia in the doses used in a clinical setting. Due to the likely carcinogenic effect, PPIs should be used carefully. Moreover, since the carcinogenic effect of Helicobacter pylori (Hp) infection also may be mediated by an increase in gastrin, Hp should be eradicated whenever treatment with PPI is initiated. In peptic ulcer disease Hp eradication is the treatment of choice. Gastro-oesophageal reflux disease (GERD) is the most prevalent condition leading to long-term use of inhibitors of gastric acid secretion. Only in severe oesophagitis should the treatment be initiated by PPIs, whereas histamine-2 (H-2) blockers ought to be the initial option in most cases of GERD particularly since PPI treatment induc...Continue Reading

References

Jan 1, 1991·Scandinavian Journal of Gastroenterology. Supplement·H L WaldumA K Sandvik
Jan 1, 1990·Digestion·Y TielemansR Håkanson
Apr 21, 1972·Nature·J W BlackE M Parsons
Mar 1, 1984·Histopathology·E WilanderP Pitkänen
Nov 5, 1997·International Journal of Cancer. Journal International Du Cancer·P ClercD Fourmy
Apr 2, 1999·Alimentary Pharmacology & Therapeutics·S SanduleanuR W Stockbrügger
Feb 5, 2000·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·G QvigstadH L Waldum
Jun 18, 2002·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Gunnar QvigstadHelge L Waldum
Oct 1, 1963·The Journal of Pathology and Bacteriology·J G AZZOPARDI, D J POLLOCK
Jun 30, 1955·The New England Journal of Medicine·N ZAMCHECKL NORMAN
Jun 30, 2004·Scandinavian Journal of Gastroenterology·H L WaldumG Qvigstad
Feb 1, 2005·Alimentary Pharmacology & Therapeutics·R FossmarkH L Waldum
Dec 14, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Karin BakkelundHelge Waldum
May 19, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Constantin S JianuHelge L Waldum
Jul 29, 2011·Journal of Gastroenterology and Hepatology·Masaki MiyamotoNoriaki Manabe
Sep 25, 2012·Alimentary Pharmacology & Therapeutics·R FioccaUNKNOWN LOTUS trial collaborators
Mar 5, 2014·Experimental and Molecular Pathology·Øystein SørdalHelge Waldum
Dec 7, 2014·Digestive Diseases and Sciences·Helge L WaldumReidar Fossmark
Oct 6, 2017·Hormones & Cancer·Patricia MjønesHelge L Waldum
Jan 24, 2018·Journal of the National Cancer Institute·William F AndersonM Constanza Camargo

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Citations

Mar 12, 2019·Scandinavian Journal of Gastroenterology·Shih-Wei Lai
May 23, 2019·World Journal of Gastroenterology : WJG·Moon Kyung JooHoon Jai Chun
Mar 20, 2019·Therapeutic Advances in Gastroenterology·Ka Shing Cheung, Wai K Leung
Jun 4, 2020·International Journal of Molecular Sciences·Takamitsu SasakiHiroki Kuniyasu
Apr 14, 2021·Journal of Pediatric Gastroenterology and Nutrition·Rok OrelNikhil Thapar
Mar 31, 2019·La Presse médicale·Sophie RibiereRomain Coriat
Jun 2, 2021·European Journal of Clinical Pharmacology·Takahiro SuzukiTakahisa Furuta
Jul 3, 2021·International Journal of Molecular Sciences·Helge Waldum, Reidar Fossmark
Aug 27, 2021·Expert Opinion on Pharmacotherapy·Taraneh MousaviMohammad Abdollahi

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