Proton pump inhibitors' use and risk of hip fracture: a systematic review and meta-analysis

Rheumatology International
Salman HussainAbul Kalam Najmi

Abstract

In the last decade, epidemiological studies presented inconsistent findings concerning the proton pump inhibitors (PPI) use and the risk of hip fracture. So, this systematic review and meta-analysis were performed with the aim to quantify the risk of hip fracture associated with PPI use. PubMed® and Cochrane Central databases were searched from inception to January 2018. The quality of included studies in meta-analysis was assessed using Newcastle-Ottawa scale. Primary outcome of this study was to assess the risk of hip fracture among PPI user. Secondary outcomes include subgroup analysis based on study design, study quality, duration of PPI use, calcium intake, and geographical region. Sensitivity analysis was also performed. Review Manager (RevMan) was used to perform statistical analysis. This meta-analysis was based on seventeen studies. Pooled risk ratio showed a statistically significant association between PPI use and hip fracture risk (RR 1.26 [95% CI 1.17-1.35], p < 0.00001). Subgroup analysis, based on the study design, showed a highly significant association between PPI use and risk of hip fracture (p < 0.0001). The risk of hip fracture persisted even when stratified by calcium adjustment and the duration of PPI use ...Continue Reading

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Citations

Jan 8, 2019·Journal of Gastroenterology and Hepatology·Salman HussainAbul Kalam Najmi
Jan 25, 2019·The American Journal of Gastroenterology·Toshihiro Sugiyama
Aug 3, 2019·The International Journal of Pharmacy Practice·Kim SearsElizabeth G VanDenKerkhof
Aug 31, 2019·European Journal of Clinical Pharmacology·Quentin DardonvilleHaleh Bagheri
Dec 7, 2019·Current Gastroenterology Reports·Takeshi Kanno, Paul Moayyedi
Jul 25, 2019·Journal of Gastroenterology and Hepatology·Salman HussainAbul Kalam Najmi
Oct 4, 2019·BMJ : British Medical Journal·Emma SverdénJesper Lagergren
Aug 1, 2019·World Journal of Transplantation·Boonphiphop BoonphengWisit Cheungpasitporn
Jan 30, 2021·International Journal of Endocrinology·Silvia Irina BrigantiAndrea Palermo
Jun 12, 2021·Alimentary Pharmacology & Therapeutics·Elizabeth M SalvoPeter J Kahrilas
Nov 23, 2021·The American Journal of Gastroenterology·Philip O KatzStuart Jon Spechler

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