Proton range shift analysis on brain pseudo-CT generated from T1 and T2 MR

Acta Oncologica
Giampaolo PileggiMaria Francesca Spadea

Abstract

In radiotherapy, MR imaging is only used because it has significantly better soft tissue contrast than CT, but it lacks electron density information needed for dose calculation. This work assesses the feasibility of using pseudo-CT (pCT) generated from T1w/T2w MR for proton treatment planning, where proton range comparisons are performed between standard CT and pCT. MR and CT data from 14 glioblastoma patients were used in this study. The pCT was generated by using conversion libraries obtained from tissue segmentation and anatomical regioning of the T1w/T2w MR. For each patient, a plan consisting of three 18 Gy beams was designed on the pCT, for a total of 42 analyzed beams. The plan was then transferred onto the CT that represented the ground truth. Range shift (RS) between pCT and CT was computed at R80 over 10 slices. The acceptance threshold for RS was according to clinical guidelines of two institutions. A γ-index test was also performed on the total dose for each patient. Mean absolute error and bias for the pCT were 124 ± 10 and -16 ± 26 Hounsfield Units (HU), respectively. The median and interquartile range of RS was 0.5 and 1.4 mm, with highest absolute value being 4.4 mm. Of the 42 beams, 40 showed RS less than the c...Continue Reading

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Citations

Sep 12, 2019·Physics in Medicine and Biology·Lucas N Burigo, Bradley M Oborn
Oct 28, 2019·The British Journal of Radiology·Francesca AlbertiniAntony Lomax
Jan 31, 2020·International Journal of Particle Therapy·Ghazal Shafai-ErfaniXiaofeng Yang
Jul 1, 2020·Annals of Biomedical Engineering·Paolo ZaffinoMaria Francesca Spadea
May 31, 2020·Radiation Oncology·Aswin HoffmannKatia Parodi
Nov 11, 2020·Zeitschrift für medizinische Physik·Hatice Selcen DumluMarco Riboldi
Nov 18, 2019·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nicolas DepauwHanne Kooy
Aug 19, 2021·Medical Physics·Maria Francesca SpadeaJoao Seco

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