Proton SBRT for medically inoperable stage I NSCLC.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Kenneth WestoverHenning Willers

Abstract

The physical properties of proton beam radiation may offer advantages for treating patients with non-small-cell lung cancer (NSCLC). However, its utility for the treatment of medically inoperable stage I NSCLC patients with stereotactic body radiation therapy (SBRT) is unknown. Outcomes for patients with medically inoperable stage I NSCLC treated with proton SBRT were retrospectively analyzed. Proton SBRT was selected as the treatment modality based on pulmonary comorbidities (n = 5), prior chest radiation or/and multiple primary tumors (n = 7), or other reasons (n = 3). Treatments were administered using 2 to 3 proton beams. Treatment toxicity was scored according to common toxicity criteria for adverse events version 4 criteria. Fifteen consecutive patients and 20 tumors were treated with proton SBRT to 42 to 50 Gy(relative biological effectiveness) in 3 to 5 fractions between July 2008 and September 2010. Treatments were well tolerated with only one case of grade 2 fatigue, one case of grade 2 dermatitis, three cases of rib fracture (maximum grade 2), and one case of grade 3 pneumonitis in a patient with severe chronic obstructive pulmonary disease. With a median follow-up of 24.1 months, 2-year overall survival and local co...Continue Reading

References

Jul 17, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tiziana RancatiGiovanni Mauro Cattaneo
Oct 16, 2004·Chest·David A BushJames M Slater
Nov 3, 2005·The European Respiratory Journal·R PellegrinoJ Wanger
Dec 8, 2005·Physics in Medicine and Biology·Hanne M KooyJacob B Flanz
Feb 7, 2006·International Journal of Radiation Oncology, Biology, Physics·Keiji NiheiHideki Nishimura
Feb 16, 2006·Medical Physics·Martijn Engelsman, Hanne M Kooy
Apr 4, 2006·International Journal of Radiation Oncology, Biology, Physics·Martijn EngelsmanHanne M Kooy
Oct 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert TimmermanJames Fletcher
Apr 15, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Dietmar GeorgRichard Pötter
Jun 3, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kevin L StephansGregory M M Videtic
Dec 10, 2009·Nature Reviews. Clinical Oncology·Simon S LoRobert D Timmerman
Mar 18, 2010·JAMA : the Journal of the American Medical Association·Robert TimmermanHak Choy
Aug 6, 2010·Seminars in Radiation Oncology·Clifford G Robinson, Jeffrey D Bradley
Oct 12, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Bradford S HoppeZuofeng Li
Jan 22, 2011·International Journal of Radiation Oncology, Biology, Physics·Joe Y ChangJames D Cox

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Citations

May 28, 2013·The Cancer Journal·Terence M Williams, Adam Maier
Aug 20, 2014·BioMed Research International·Jonathan D Grant, Joe Y Chang
Sep 10, 2014·International Journal of Radiation Oncology, Biology, Physics·Dirk De RuysscherJohannes A Langendijk
Apr 17, 2016·International Journal of Radiation Oncology, Biology, Physics·Joe Y ChangUNKNOWN International Particle Therapy Co-operative Group Thoracic Subcommittee
Apr 17, 2016·International Journal of Radiation Oncology, Biology, Physics·Qi LiuHenning Willers
Apr 4, 2015·International Journal of Radiation Oncology, Biology, Physics·Qi LiuHenning Willers
Sep 24, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Osamu FujiiNobukazu Fuwa
Jun 11, 2016·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Sung Uk LeeYeon-Joo Kim
Aug 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Timur Mitin, Anthony L Zietman
Aug 17, 2014·Radiation Oncology·Nor Shazrina SulaimanNobukazu Fuwa
Apr 6, 2019·Australasian Physical & Engineering Sciences in Medicine·Hossein AslianMara Severgnini
Mar 14, 2013·Expert Review of Medical Devices·Yoshiko Oshiro, Hideyuki Sakurai
Apr 3, 2019·International Journal of Clinical Oncology·Hiroshi DoiYasumasa Nishimura
Jan 10, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Stanislav LazarevCharles B Simone
Nov 30, 2018·International Journal of Radiation Oncology, Biology, Physics·Feng-Ming Spring KongEllen Yorke
Feb 22, 2021·Seminars in Radiation Oncology·Harald PaganettiGregory C Sharp
Apr 8, 2019·International Journal of Radiation Oncology, Biology, Physics·Percy LeeX Allen Li
May 7, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Tobias FinazziSuresh Senan

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