PMID: 9436947Jan 22, 1998Paper

Proton spectroscopy of human brain with very short echo time using high gradient amplitudes

Magnetic Resonance Imaging
Uwe SeegerWolfgang Grodd

Abstract

In localized proton magnetic resonance spectroscopy very short echo times (TE) are achieved to diminish signal loss due to T2 relaxation and to avoid phase distortions due to J-coupling. A sequence for single volume spectroscopy in human brain is described with a TE as low as 5 ms. Examinations were performed on a 1.5 T whole-body imager with actively shielded gradients. A self-designed stimulated echo acquisition mode (STEAM) sequence with very high amplitude spoiling gradients of 24 mT/m was used to take advantage of the whole potential of the gradient system. Optimization of TE was carried out by controlling spectral quality and localization in both phantom and volunteer measurements. Proton spectra of human brain were acquired in 21 healthy volunteers. Spectra of occipital white matter, parieto-occipital grey/white matter, and cerebellum revealed none or only small eddy current distortions at a TE of 5 ms. The volume of interest was 8-12 ml, repetition time was 1.5 s, and mixing time was 5 ms. Peak ratios of major metabolites referring to creatine were estimated and the relative standard deviations were calculated to determine interindividual reproducibility. The relative standard deviation of myo-inositol ranged from 6% to...Continue Reading

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Citations

Dec 7, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·V MlynárikE Moser
Feb 24, 1999·Alcoholism, Clinical and Experimental Research·D SeitzW Grodd
Sep 25, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kai Zhong, Thomas Ernst
Mar 26, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ralf MekleRolf Gruetter
Oct 27, 2009·Journal of Magnetic Resonance Imaging : JMRI·Ileana Hancu
Nov 14, 2008·NMR in Biomedicine·Ileana Hancu
Sep 23, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Vladimír MlynárikRolf Gruetter
Jul 31, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yan ZhangJun Shen
Jan 26, 2011·NMR in Biomedicine·Ileana Hancu, John Port
May 12, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Assaf TalOded Gonen
Nov 9, 2005·Magnetic Resonance Imaging·Jack Knight-ScottS Andrea Dunham
Dec 1, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Vladimír MlynárikRolf Gruetter
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Jul 31, 2016·Journal of Magnetic Resonance Imaging : JMRI·Jack Knight-ScottXiaodong Zhong
Aug 4, 2006·Physics in Medicine and Biology·Stephen F Keevil

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