Proton stereotactic radiosurgery in management of persistent acromegaly.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Joshua H PetitJay S Loeffler

Abstract

To evaluate the efficacy and safety of proton stereotactic radiosurgery (PSRS) for acromegaly that is refractory to surgical treatment and medication. From 1992 to 2003, 22 patients were treated at our institution for persistent acromegaly with use of PSRS. All patients had undergone at least one transsphenoidal surgical procedure without biochemical cure. The median treatment dose delivered during PSRS was 20 (range, 15 to 24) cobalt gray equivalents. Follow-up was available for all patients at a median of 6.3 (range, 2.5 to 14.2) years after PSRS. A response to PSRS was observed in 21 of 22 patients (95%). A complete response (CR), defined as sustained (> or =3 months) normalization of insulinlike growth factor-I without medical suppression, was attained in 13 patients (59%). Among patients with CR, the median time to CR was 42 (range, 6 to 62) months. No visual complications, seizures, clinical evidence of brain injury, or secondary tumors were noted on regular magnetic resonance imaging scans. One patient had complete pituitary dysfunction before PSRS and was therefore excluded from evaluation for failure. Of the other 21 patients, 8 (38%) had new pituitary deficits. These results demonstrate that PSRS is effective for pers...Continue Reading

References

Mar 28, 1968·The New England Journal of Medicine·R N KjellbergB Kliman
Jul 1, 1994·Clinical Endocrinology·C RajasooryaH K Ibbertson
Mar 30, 1994·International Journal of Radiation Oncology, Biology, Physics·H M KooyJ S Loeffler
Sep 1, 1993·Radiology·S D ClarkeD S Baskin
Sep 30, 1993·International Journal of Radiation Oncology, Biology, Physics·R B TishlerJ C Flickinger
Mar 1, 1993·Journal of Endocrinological Investigation·J EtxabeJ A Vazquez
Oct 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R W TsangW J Simpson
Oct 13, 1998·The Journal of Clinical Endocrinology and Metabolism·A AboschC B Wilson
Jul 21, 2000·The Journal of Clinical Endocrinology and Metabolism·N R BiermaszF Roelfsema
Sep 11, 2001·The Journal of Clinical Endocrinology and Metabolism·J KreutzerE R Laws
Nov 27, 2001·European Journal of Endocrinology·R CozziR Attanasio
Jan 10, 2003·Clinical Endocrinology·Catherine BeauregardOmar Serri
Jun 14, 2003·Endocrine Journal·Kazunori AritaFumiyoshi Kasagi
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Roberto AttanasioMaura Arosio
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·Omar SerriJules Hardy
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·Ian M HoldawayGreg D Gamble
Jan 27, 2005·Clinical Endocrinology·Giuseppe MinnitiRiccardo Maurizi Enrici
May 19, 2005·The Journal of Clinical Endocrinology and Metabolism·Frédéric CastinettiThierry Brue
May 3, 2006·Clinical Endocrinology·Jana JezkováLadislav Pecen
Feb 3, 2007·Pituitary·Brian K RobertsLaurence Katznelson

❮ Previous
Next ❯

Citations

Dec 18, 2007·Reviews in Endocrine & Metabolic Disorders·Helen A Shih, Jay S Loeffler
Aug 6, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·P J WilsonR I Smee
Sep 3, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Brooke Swearingen, Jay Loeffler
Apr 21, 2012·International Journal of Endocrinology·Yvette MarquezGabriel Zada
Dec 6, 2011·Radiation Oncology·Giuseppe MinnitiRiccardo Maurizi Enrici
Dec 18, 2012·Radiation Oncology·Maurizio AmichettiGiuseppe Minniti
Jan 30, 2013·International Journal of General Medicine·Daphne T AdelmanBert Bakker
Feb 6, 2010·European Journal of Endocrinology·S RougU Feldt-Rasmussen
Dec 24, 2015·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Marco KrengliLaura Masini
Mar 12, 2013·Seminars in Radiation Oncology·Stephanie E CombsMichael Brada
Oct 9, 2012·Neurosurgery Clinics of North America·Jason P SheehanMark J Lobo
Apr 30, 2010·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·A Bouyon-MonteauP Bey
Aug 8, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Abd Moain Abu DabrhMohammad Hassan Murad
Jan 13, 2015·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Jan Patrick BoströmKlaus Hamm
Aug 14, 2010·Orvosi hetilap·Judit DénesMiklós Góth
Mar 20, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Abd Abu DabrhMohammad Murad
Sep 10, 2014·International Journal of Radiation Oncology, Biology, Physics·Daniel A WattsonHelen A Shih
Apr 21, 2012·International Journal of Endocrinology·G MinnitiR Maurizi Enrici
Oct 13, 2016·Radiation Oncology·Giuseppe MinnitiMaximillian Niyazi
Oct 5, 2010·Neurosurgical Focus·Nathan C Rowland, Manish K Aghi
Jan 27, 2018·Pituitary·Giuseppe MinnitiSergio Paolini
Feb 24, 2010·Nature Reviews. Endocrinology·Frederic CastinettiThierry Brue
Sep 18, 2012·Radiation Oncology Journal·Chai Hong RimChul Yong Kim
Jun 6, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity·Manish Aghi, Lewis S Blevins
Nov 1, 2015·Expert Review of Endocrinology & Metabolism·Ferdinand Roelfsema, Gerrit van den Berg
Aug 24, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Laurence KatznelsonUNKNOWN American Association of Clinical Endocrinologists
Nov 27, 2018·Neurosurgery·Jennifer VogelRobert A Lustig
Jul 27, 2020·Endocrinology, Diabetes & Metabolism·Nikolaos KyriakakisRobert D Murray
Feb 18, 2017·Pituitary·Monica Livia Gheorghiu
Jan 7, 2021·Biomedicines·Eric J LehrerDaniel M Trifiletti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Related Papers

International Journal of Radiation Oncology, Biology, Physics
Brian B RonsonJ M Slater
Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Yoshiyasu IwaiKatsunobu Yoshioka
© 2021 Meta ULC. All rights reserved