Proton therapy of uveal melanomas in Berlin. 5 years of experience at the Hahn-Meitner Institute

Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
Stefan HöchtWolfgang Hinkelbein

Abstract

In June 1998, proton-beam therapy of ocular tumors started at the Hahn-Meitner Institute Berlin, Germany. The purpose of the present study is to evaluate treatment outcome for uveal melanomas. 245 consecutive patients with primary melanoma of the uvea were treated from June 1998 to April 2003 with a 68-MeV proton beam. In 96.2% of all patients, a uniform fractionation scheme was applied: single dose 15 CGE (cobalt gray equivalent), total dose 60 CGE on 4 consecutive days. Follow-up is available in 229 patients. At the time of median follow-up (18.4 months), local control is 96.4% and 95.5% at 3 years. Eye retention rate is 92.6% at 20 months (median follow-up) and 87.5% at 3 years. Proton-beam irradiation of uveal melanomas at the Hahn-Meitner Institute after the first 5 years of its initiation reveals local tumor control and eye retention rates in the range of other centers with larger experience. Delivering high treatment quality in hadron therapy from the beginning has been achieved.

Citations

Jul 10, 2013·Journal of Radiation Research·Stephanie E CombsJürgen Debus
Mar 24, 2011·The British Journal of Radiology·A D JensenJ Debus
Nov 27, 2009·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Barbara MichalecPaweł Olko
Dec 5, 2006·International Journal of Radiation Oncology, Biology, Physics·Naoki HirasawaHirohiko Tsujii
Mar 11, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Aline I RiechardtAntonia M Joussen
Dec 24, 2005·Medical Physics·Inder k DaftariTheodore L Phillips
Mar 14, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniela Schulz-Ertner, Hirohiko Tsujii
Mar 14, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael BradaDirk De Ruysscher
Oct 9, 2009·Medical Physics·Alfred SmithKoji Matsuda
Aug 5, 2006·International Journal of Radiation Oncology, Biology, Physics·Stefan HöchtWolfgang Hinkelbein
May 16, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Mark LodgeTom Jefferson
Nov 30, 2016·International Ophthalmology Clinics·Ronald W MilamAnthony B Daniels
Jun 8, 2017·International Journal of Radiation Oncology, Biology, Physics·Juliette ThariatJean Pierre Caujolle
Apr 20, 2017·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Tae Wan KimSung Ho Moon
Aug 13, 2009·The Cancer Journal·Daniela Schulz-Ertner
May 12, 2012·Journal of Cutaneous Pathology·Gerardo FerraraCatherine M Stefanato
Aug 6, 2013·The British Journal of Dermatology·S SeidenariC Magnoni
Jul 20, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Aline I RiechardtAntonia M Joussen
Apr 14, 2018·Journal of Korean Medical Science·Youn Joo ChoiYoung Suk Yu
Dec 4, 2012·Physics in Medicine and Biology·A WeberJ Heufelder
Dec 11, 2019·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Salvatore GrisantiVinodh Kakkassery
Apr 17, 2009·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Geertruida E BekkeringJos Kleijnen
Nov 17, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Eva OberackerThoralf Niendorf

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