Proton translocation by transhydrogenase

FEBS Letters
J Baz Jackson

Abstract

Transhydrogenase, in animal mitochondria and bacteria, couples hydride transfer between NADH and NADP(+) to proton translocation across a membrane. Within the protein, the redox reaction occurs at some distance from the proton translocation pathway and coupling is achieved through conformational changes. In an 'open' conformation of transhydrogenase, in which substrate nucleotides bind and product nucleotides dissociate, the dihydronicotinamide and nicotinamide rings are held apart to block hydride transfer; in an 'occluded' conformation, they are moved into apposition to permit the redox chemistry. In the two monomers of transhydrogenase, there is a reciprocating, out-of-phase alternation of these conformations during turnover.

References

Dec 14, 1976·Biochemistry·W J Albery, J R Knowles
Sep 1, 1992·Biophysical Journal·W J Bruno, W Bialek
Oct 1, 1991·Journal of Bioenergetics and Biomembranes·J B Jackson
Aug 15, 1988·The Biochemical Journal·J B Hoek, J Rydström
Mar 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Y Hatefi, M Yamaguchi
Jun 26, 1999·The Journal of Biological Chemistry·J Meuller, J Rydström
Dec 3, 1999·Nature Structural Biology·G S PrasadC D Stout
Dec 10, 1999·Microbial & Comparative Genomics·W K StudleyM H Saier
Dec 28, 1999·FEBS Letters·J B JacksonS A White
Jun 28, 2002·The Journal of Biological Chemistry·Mutsuo YamaguchiYoussef Hatefi
Oct 16, 2002·Biochemistry·G Sridhar PrasadC David Stout

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Citations

Jul 21, 2009·Proceedings of the National Academy of Sciences of the United States of America·Xinning ZhangAlex L Sessions
Jun 2, 2007·The Journal of Biological Chemistry·Miguel A AonBrian O'Rourke
Sep 11, 2009·Antioxidants & Redox Signaling·Giorgio Lenaz, Maria Luisa Genova
Feb 1, 2011·Applied and Environmental Microbiology·Matthias RabergAlexander Steinbüchel
May 3, 2012·American Journal of Physiology. Endocrinology and Metabolism·Joshua P GrayEmma A Heart
Nov 16, 2006·PLoS Biology·Kathleen M ScottGary T Zeruth
Aug 26, 2009·The International Journal of Biochemistry & Cell Biology·Petr Jezek, Lydie Plecitá-Hlavatá
Jul 5, 2008·Biophysical Journal·Karina Tveen JensenJ Baz Jackson
Jan 25, 2005·Trends in Parasitology·Fiona L HenriquezCraig W Roberts
Sep 1, 2006·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Felix C MarkHans O Pörtner
Aug 17, 2005·The International Journal of Biochemistry & Cell Biology·Petr Jezek, Lydie Hlavatá
Sep 23, 2014·Biological Reviews of the Cambridge Philosophical Society·Anna StinconeMarkus Ralser
Jun 11, 2010·Essays in Biochemistry·Peter R Rich, Amandine Maréchal
Aug 19, 2015·Frontiers in Microbiology·Sebastiaan K SpaansServé W M Kengen
Aug 25, 2010·Biochimica Et Biophysica Acta·Lucinda HuxleyJ Baz Jackson
Jan 19, 2010·Biochimica Et Biophysica Acta·Giulia VeronesiJ Baz Jackson
Feb 12, 2008·Experimental Parasitology·Nancy Mercer-Haines, Carmen F Fioravanti
Jun 7, 2005·Biochimica Et Biophysica Acta·Tania BizouarnJ Baz Jackson
Jun 10, 2009·Biochimica Et Biophysica Acta·Simon J WhiteheadJ Baz Jackson
Dec 17, 2014·Frontiers in Physiology·Ramya VajapeyPeter Abadir
Jun 7, 2014·Frontiers in Genetics·Mario López-PérezFrancisco Rodriguez-Valera
Jul 26, 2016·Frontiers in Microbiology·William D LeavittAlexander S Bradley
Jun 1, 2017·Antioxidants & Redox Signaling·Gaetano CalabreseJan Riemer
Nov 25, 2003·FEBS Letters·J Baz Jackson
May 27, 2014·Applied and Environmental Microbiology·Katharina WiegmannRalf Rabus
Feb 25, 2006·Human Molecular Genetics·Ting-Ting HuangCharles J Epstein
Mar 15, 2006·The Journal of Biological Chemistry·T Harma C BrondijkJ Baz Jackson
Nov 18, 2018·Journal of Industrial Microbiology & Biotechnology·Milin ZhanYe Ni
Sep 15, 2006·American Journal of Physiology. Cell Physiology·D Thor JohnsonRobert S Balaban
Aug 11, 2010·Molecular and Cellular Biochemistry·Jason R TrebergJohn T Brosnan

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