PMID: 9170386May 1, 1997Paper

Protooncogene expression in osteogenesis induced by bone morphogenetic protein

Clinical Orthopaedics and Related Research
S SakanoH Seo

Abstract

In this study, changes in the expression of protooncogenes c-fos and c-myc messenger ribonucleic acid were investigated in mice after implantation of bone morphogenetic protein. The expression of c-fos showed a biphasic pattern. The first increase was observed on Day 1 with the aggregation of round cells. The second increase was observed on Day 7 with the appearance of chondroblasts. The amount of c-myc messenger ribonucleic acid showed the sustained high levels from Days 2 to 7. During this period, the proliferation of mesenchymal cells was histologically evident. After Day 11, the expression of c-fos and c-myc decreased and remained at low levels despite the progress in chondroosteogenesis. The protooncogenes c-fos and c-myc appear to increase before calcification in the process of bone morphogenetic protein induced bone and cartilage development.

References

Dec 24, 1992·Nature·Z Q WangE F Wagner
Jan 1, 1992·Developmental Biology·R QuartoR Cancedda
Sep 1, 1990·The Journal of Cell Biology·E I ClossP G Strauss
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A J CelesteJ M Wozney
Jan 1, 1986·Annual Review of Genetics·M D Cole
May 13, 1983·Science·M R UristG A Finerman
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·F van StraatenI M Verma
Aug 1, 1993·The Journal of Cell Biology·A E GrigoriadisE F Wagner

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Citations

Mar 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A D DiwanG A Murrell
Mar 18, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jin Yan, Barbara F Hales
Jun 11, 2002·Biochemical and Biophysical Research Communications·Shinji SakanoHisao Seo

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