Protopanaxatirol type ginsenoside Re promotes cyclic growth of hair follicles via inhibiting transforming growth factor β signaling cascades

Biochemical and Biophysical Research Communications
Zheng LiChulhee Choi

Abstract

Ginsenosides, the major bio-active ingredients included in Panax ginseng, have been known for the hair growth activity and used to treat patients who suffer from hair loss; however, the detailed mechanisms of this action are still largely unknown. This study was conducted to investigate the molecular and cellular mechanisms responsible for hair growth promoting effect of ginsenoside Re (GRe) in vitro and in vivo. Different doses of minoxidil and GRe were administered topically to the back regions of nude mice for up to 45 days, and hair shaft length and hair cycles were determined for hair promoting activities. Topical treatment of GRe significantly increased the hair shaft length and hair existent time, which was comparable to the action of minoxidil. We also demonstrated that GRe stimulated hair shaft elongation in the ex vivo cultures of vibrissa hair follicles isolated from C57BL/6 mouse. Systemic transcriptome analysis by next generation sequencing demonstrated that TGF-β-pathway related genes were selectively down-regulated by treatment of GRe in vivo, and the same treatment suppressed TGF-β-induced phosphorylation of ERK in HeLa cells. The results clearly indicated that GRe is the effective constituent in the ginseng on ...Continue Reading

References

May 23, 2002·Developmental Cell·Thomas AndlSarah E Millar
Apr 26, 2003·The Journal of Biological Chemistry·Kingston K L Mak, Siu Yuen Chan
Nov 19, 2003·Developmental Biology·Kinga MichnoPaul A Hamel
Dec 4, 2003·Current Opinion in Cell Biology·Laure Gambardella, Yann Barrandon
Jan 8, 2004·The Journal of Investigative Dermatology·Tsutomu SomaLaurel A Raftery
Jun 15, 2004·Journal of Dermatological Science·Toshihiko Hibino, Toshio Nishiyama
Jan 31, 2006·Journal of Cell Science·Laura Alonso, Elaine Fuchs
Jun 17, 2006·The Journal of Investigative Dermatology·D Ben AmitaiZ Laron
Mar 11, 2008·Cell·Toshio Suda, Fumio Arai
Jun 13, 2008·The British Journal of Dermatology·A NaitoM Ohdera
Feb 13, 2009·Current Biology : CB·Marlon R SchneiderRalf Paus
Oct 8, 2009·The Journal of Investigative Dermatology·Tace RicoRobert S Kirsner
Oct 1, 2011·Journal of Ethnopharmacology·Soojin ParkJinnyoung Ho
Dec 27, 2011·Pharmacology, Biochemistry, and Behavior·Yao-Wu LiuXiao-Xing Yin
Jan 28, 2015·Clinical and Experimental Dermatology·Y-S SuZ-Q Hu

❮ Previous
Next ❯

Citations

Sep 9, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Van-Long TruongWoo-Sik Jeong
Sep 14, 2018·International Journal of Molecular Sciences·Bu Young Choi
Sep 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kristelle HughesPhila Raharivelomanana
Jan 18, 2020·International Journal of Molecular Sciences·Eleonora BassinoLuca Munaron

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.