Protoparvovirus Interactions with the Cellular DNA Damage Response

Viruses
Kinjal MajumderDavid J Pintel

Abstract

Protoparvoviruses are simple single-stranded DNA viruses that infect many animal species. The protoparvovirus minute virus of mice (MVM) infects murine and transformed human cells provoking a sustained DNA damage response (DDR). This DDR is dependent on signaling by the ATM kinase and leads to a prolonged pre-mitotic cell cycle block that features the inactivation of ATR-kinase mediated signaling, proteasome-targeted degradation of p21, and inhibition of cyclin B1 expression. This review explores how protoparvoviruses, and specifically MVM, co-opt the common mechanisms regulating the DDR and cell cycle progression in order to prepare the host nuclear environment for productive infection.

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Citations

Jul 12, 2018·Annual Review of Virology·Matthew D Weitzman, Amélie Fradet-Turcotte
Feb 6, 2020·Viruses·Matthew Charman, Matthew D Weitzman
Jul 1, 2020·Annual Review of Virology·Anna HartleyAntonio Marchini
Jun 21, 2019·Viruses·Clemens Bretscher, Antonio Marchini
Aug 11, 2021·Viruses·Salla MattolaMaija Vihinen-Ranta

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Methods Mentioned

BETA
ubiquitination
Infection
acetylation

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