Protoporphyrinogen oxidase and ferrochelatase in porphyria variegata

European Journal of Clinical Investigation
D J ViljoenS Kramer

Abstract

Protoporphyrinogen oxidase activity and ferrochelatase activity were measured in leucocytes from patients with porphyria variegata. The mean activity of protoporphyrinogen oxidase (PPO) in porphyria variegata (PV) was about 50% of normal (P less than 0.05). The mean activity of ferrochelatase with 59Fe2+ sulphate and protoporphyrin as substrates (in the presence of ascorbic acid) was reduced by 40% (P less than 0.009). The mean activity of ferrochelatase with 59Fe3+ chloride and protoporphyrin as substrates (in the presence of reduced glutathione) was increased by 65% (P less than 0.005). Both are statistically highly significant. The findings are interpreted as follows: (a) The occurrence of a low level of protoporphyrinogen oxidase in PV is confirmed. (b) The findings indicate a concurrent structural change in ferrochelatase (this may be structurally related to (a) but no evidence of this is at present available).

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Citations

May 16, 1991·The New England Journal of Medicine·G M LoganJ R Bloomer
Jun 1, 1986·European Journal of Clinical Investigation·P N MeissnerE Harley
Oct 1, 1994·Occupational and Environmental Medicine·R I HollandH Kjuus
Apr 1, 1985·Clinics in Dermatology·M R Moore, P B Disler
Oct 1, 1985·Archives of Biochemistry and Biophysics·J M CamadroR D Levere

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