Protracted Administration of L-Asparaginase in Maintenance Phase Is the Risk Factor for Hyperglycemia in Older Patients with Pediatric Acute Lymphoblastic Leukemia

PloS One
Hideki YoshidaJapan Association of Childhood Leukemia Study

Abstract

Although L-asparaginase related hyperglycemia is well known adverse event, it is not studied whether the profile of this adverse event is affected by intensification of L-asparaginase administration. Here, we analyzed the profile of L-asparaginase related hyperglycemia in a 1,176 patients with pediatric acute lymphoblastic leukemia treated according to the Japan Association of Childhood Leukemia Study ALL-02 protocol using protracted L-asparaginase administration in maintenance phase. We determined that a total of 75 L-asparaginase related hyperglycemia events occurred in 69 patients. Although 17 events (17/1176, 1.4%) developed in induction phase, which was lower incidence than those (10-15%) in previous reports, 45 events developed during the maintenance phase with protracted L-asparaginase administration. Multivariate analysis showed that older age at onset (≥ 10 years) was a sole independent risk factor for L-asparaginase-related hyperglycemia (P<0.01), especially in maintenance phase. Contrary to the previous reports, obesity was not associated with L-asparaginase-related hyperglycemia. These findings suggest that protracted administration of L-asparaginase is the risk factor for hyperglycemia when treating adolescent and ...Continue Reading

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Jan 24, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kenichi SakamotoKeizo Horibe
Nov 22, 2016·Genes, Chromosomes & Cancer·Kenichi SakamotoAtsushi Sato
Sep 19, 2019·Journal of the National Cancer Institute. Monographs·Allison GrimesJane Lynch
Oct 30, 2018·Current Diabetes Reports·Valentina FattorussoAdriana Franzese

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