Protracted anaphylaxis developed after peginterferon α-2a administration for chronic hepatitis C

World Journal of Gastroenterology : WJG
Akihiko SakataniKazuo Kinoshita

Abstract

Peginterferon is a key drug used to treat chronic viral hepatitis that is known for causing various side effects. Side effects occurring immediately after administration include headache, nausea, and influenza-like symptoms, such as fever and joint pain. However, reports of anaphylactic shock are extremely rare. Here we report a patient with protracted anaphylaxis who suffered shock symptoms after peginterferon α-2a administration for chronic hepatitis C. Although the patient improved temporarily with shock treatment, symptoms of anaphylaxis recurred. As peginterferon is often administered on an outpatient basis, it is important to recognize life-threatening side effects that may develop in a protracted manner.

References

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Citations

May 20, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E Wenande, L H Garvey
Jun 7, 2019·Current Opinion in Allergy and Clinical Immunology·Anna Sala-CunillVictoria Cardona
Nov 21, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Zhao-Hua ZhouSteven Kozlowski
Apr 10, 2021·Critical Care Explorations·Ashleigh FrankRoopa Kohli-Seth

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