Abstract
Several studies suggest that protracted continuous infusion constitutes an important way to optimize the dose and the efficacy of 5-fluorouracil (5-FU) in metastatic cancer. Eighty-three women aged 27-76 (median age 55) with metastatic breast cancer were treated every 4 weeks with a continuous ambulatory venous infusion of 5-FU 350 mg/m2/day and oral cyclophosphamide 100 mg/m2/day over 15 days. The continuous therapy was associated with a weekly administration of vincristine (0.8 mg/m2) and doxorubicin (15 mg/m2) on day 1, day 8, and day 15. Cycles were repeated every 28 days. Thirty-four patients were treated in first-line metastatic chemotherapy and 49 in second-line. Toxicities included: mucositis (grade > or = 2) 23%, diarrhea (grade > or = 2) 7%, a hand-foot syndrome (grade > or = 2) 9%, alopecia (grade 3) 21%, neurological (grade > or = 2) 4%, grade 3 and 4 leukopenia 29%, and grade 3 and 4 thrombopenia 8%. Heart toxicity was only 3%. Catheter infection was observed in 1 case and 7 patients experienced thrombosis. The overall objective response rate (OR) was 48% and the complete response rate was 23%. The median duration of response was 10 months. The median survival was 16 months. Activity was better in naive than pretre...Continue Reading
References
Dec 1, 1978·British Journal of Cancer·B L HillcoatJ M Rosenfeld
Jul 1, 1975·Cancer·P SeifertV K Vaitkevicius
Oct 1, 1992·British Journal of Cancer·R A FlemingF Demard
Aug 15, 1989·Cancer·K JabbouryG Hortobagyi
Oct 1, 1989·American Journal of Clinical Oncology·A Y ChangK J Pandya
Feb 1, 1989·Cancer·S HuanV K Vaitkevicius
Mar 1, 1989·Cancer·J LokichD Williams
Aug 1, 1988·American Journal of Clinical Oncology·T MoynihanM Vukelich
Nov 1, 1987·Breast Cancer Research and Treatment·R HansenR Ausman
Sep 1, 1986·Cancer·J J LokichR Greene
Oct 1, 1985·American Journal of Clinical Oncology·J J Lokich
Jan 1, 1985·Cancer Chemotherapy and Pharmacology·Y MatsushimaN Saijo
Nov 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W Hryniuk, H Bush
Jan 1, 1983·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J LokichD Philips
May 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J E ByfieldF B Callipari
Nov 1, 1993·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E DelaFlor-WeissF M Muggia