Protracted Oxidative Alterations in the Mechanism of Hematopoietic Acute Radiation Syndrome

Antioxidants
Nikolai V Gorbunov, Pushpa Sharma

Abstract

The biological effects of high-dose total body ionizing irradiation [(thereafter, irradiation (IR)] are attributed to primary oxidative breakage of biomolecule targets, mitotic, apoptotic and necrotic cell death in the dose-limiting tissues, clastogenic and epigenetic effects, and cascades of functional and reactive responses leading to radiation sickness defined as the acute radiation syndrome (ARS). The range of remaining and protracted injuries at any given radiation dose as well as the dynamics of post-IR alterations is tissue-specific. Therefore, functional integrity of the homeostatic tissue barriers may decline gradually within weeks in the post-IR period culminating with sepsis and failure of organs and systems. Multiple organ failure (MOF) leading to moribundity is a common sequela of the hemotapoietic form of ARS (hARS). Onset of MOF in hARS can be presented as "two-hit phenomenon" where the "first hit" is the underlying consequences of the IR-induced radiolysis in cells and biofluids, non-septic inflammation, metabolic up-regulation of pro-oxidative metabolic reactions, suppression of the radiosensitive hematopoietic and lymphoid tissues and the damage to gut mucosa and vascular endothelium. While the "second hit" de...Continue Reading

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Citations

Aug 5, 2017·International Journal of Molecular Sciences·Nikolai V Gorbunov, Juliann G Kiang
Aug 25, 2017·Antioxidants & Redox Signaling·Yulia Y TyurinaValerian E Kagan
Feb 8, 2018·Journal of Cellular and Molecular Medicine·Jicong DuCong Liu
Apr 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Na ZhuYong Li
Sep 19, 2020·Current Stem Cell Reports·Raghavan ChinnaduraiChristian M Capitini
Nov 4, 2017·Scientific Reports·Subhajit GhoshPrem Kumar Indraganti
Dec 7, 2020·Medical Hypotheses·Bogdan I Gerashchenko, Vladimir G Nikolaev

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Methods Mentioned

BETA
MDA
nuclear translocation

Software Mentioned

hARS

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