Providing a diet deficient in valine but with excess leucine results in a rapid decrease in feed intake and modifies the postprandial plasma amino acid and α-keto acid concentrations in pigs

Journal of Animal Science
M GloaguenJ van Milgen

Abstract

Indispensable AA are involved in the control of feed intake. When a diet deficient in Val is offered to pigs, feed intake is typically reduced. This effect is aggravated when dietary Leu is supplied in excess of the requirement. If an unbalanced supply of branched-chain AA (BCAA) is harmful, an anorectic response may serve as a mechanism to prevent this situation. We verified this hypothesis by measuring the voluntary feed intake of a balanced diet offered during the 30-min period 1 h after ingestion of a test meal deficient or not in Val (Val- and Val+) with an excess of Leu. Twelve and four 6-wk-old crossbred female pigs were used in Exp. 1 and 2, respectively. Prior ingestion of the Val- test meal resulted in a 14% reduction in feed intake compared with that observed after ingestion of the Val+ test meal (P = 0.06) in Exp. 1, indicating that the signal to reduce feed intake occurred within 1 h. It is possible that the plasma concentration of the limiting AA serves as a signal for the dietary AA deficiency. We therefore determined the postprandial plasma concentrations of BCAA and their α-keto acids after ingestion of Val- and Val+ in 4 pigs in Exp. 2. After ingestion of the Val- diet, plasma concentrations of Val and its ket...Continue Reading

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Citations

Dec 12, 2012·Animal : an International Journal of Animal Bioscience·M GloaguenJ van Milgen
May 9, 2015·Animal : an International Journal of Animal Bioscience·E A SoumehJ V Nørgaard
Oct 19, 2016·Animal : an International Journal of Animal Bioscience·J V NørgaardH D Poulsen
Oct 19, 2016·Animal : an International Journal of Animal Bioscience·A G WesselsG I Stangl
Jan 28, 2017·Journal of Animal Science and Biotechnology·Shihai ZhangShiyan Qiao
May 29, 2015·Journal of Animal Science·E A SoumehJ V Nørgaard
Apr 4, 2019·Journal of Animal Physiology and Animal Nutrition·Dongting HeLiying Zhang
Oct 20, 2018·Animal : an International Journal of Animal Bioscience·A J M JansmanJ Th M van Diepen
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May 23, 2012·The Proceedings of the Nutrition Society·Nathalie Le Floc'hHélène Quesnel
Feb 14, 2013·Journal of Animal Science·M GloaguenJ van Milgen
Jun 27, 2019·Archives of Animal Nutrition·Nathalie Le Floc'hIsabelle Louveau
Jun 6, 2013·Journal of Animal Science·J V NørgaardE Corrent
May 4, 2017·Animal : an International Journal of Animal Bioscience·P BelloirS Tesseraud
Dec 10, 2016·Frontiers in Endocrinology·Nicholas Heeley, Clemence Blouet
May 1, 2021·Animals : an Open Access Journal From MDPI·Diana SiebertDavid Torrallardona
Aug 21, 2021·Animal : an International Journal of Animal Bioscience·L M G VerschurenA J M Jansman

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