Providing food to treat adolescents at risk for cardiovascular disease

Obesity
Sarah D de FerrantiDavid S Ludwig

Abstract

Diet modification is recommended to treat childhood cardiovascular (CV) risk factors; however, the optimal dietary strategy is unknown. In a randomized trial, the effect of a low-fat (LF) and a low-glycemic-load (LGL) reduced-calorie diet were examined in youth with overweight/obesity with CV risk factors. Using a novel intervention, we delivered LF or LGL meals and nutrition education to the home for 8 weeks (Intensive Phase), followed by 4 months Maintenance without food provision. Between-group differences in the change in insulin area under the curve (InsAUC) by oral glucose tolerance test and other risk factors were analyzed. Overall, participants (n = 27) showed substantial improvement during the Intensive Phase, including InsAUC (-59 ± 18.2 µU/ml × 120 min, P = 0.004), total cholesterol (-9.9 ± 3.6 mg/dl, P = 0.01), weight (-2.7 ± 0.5 kg, P < 0.001), waist circumference (-3.1 ± 0.8 cm, P < 0.001), HOMA-IR (-1.7 ± 0.4, P < 0.001), systolic blood pressure (-5 ± 1.4 mm Hg, P = 0.002), and CRP (-0.1 ± 0.1 mg/dl, P = 0.04). There were minimal between-group differences; the LF group showed greater declines in HDL (P = 0.005) and fasting glucose (P = 0.01) compared to the LGL group. Improvements waned during Maintenance. Home d...Continue Reading

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Citations

May 4, 2020·Advances in Nutrition·Barbara J DealNeil J Stone
Jan 8, 2020·Journal of Obesity & Metabolic Syndrome·Jieun Kim, Hyunjung Lim
Nov 22, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M I ZafarL L Chen
Dec 8, 2020·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·K DuncansonC E Collins

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Methods Mentioned

BETA
pharmacotherapy

Clinical Trials Mentioned

NCT01080339

Software Mentioned

Nutrition Data System

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