Abstract
Diet modification is recommended to treat childhood cardiovascular (CV) risk factors; however, the optimal dietary strategy is unknown. In a randomized trial, the effect of a low-fat (LF) and a low-glycemic-load (LGL) reduced-calorie diet were examined in youth with overweight/obesity with CV risk factors. Using a novel intervention, we delivered LF or LGL meals and nutrition education to the home for 8 weeks (Intensive Phase), followed by 4 months Maintenance without food provision. Between-group differences in the change in insulin area under the curve (InsAUC) by oral glucose tolerance test and other risk factors were analyzed. Overall, participants (n = 27) showed substantial improvement during the Intensive Phase, including InsAUC (-59 ± 18.2 µU/ml × 120 min, P = 0.004), total cholesterol (-9.9 ± 3.6 mg/dl, P = 0.01), weight (-2.7 ± 0.5 kg, P < 0.001), waist circumference (-3.1 ± 0.8 cm, P < 0.001), HOMA-IR (-1.7 ± 0.4, P < 0.001), systolic blood pressure (-5 ± 1.4 mm Hg, P = 0.002), and CRP (-0.1 ± 0.1 mg/dl, P = 0.04). There were minimal between-group differences; the LF group showed greater declines in HDL (P = 0.005) and fasting glucose (P = 0.01) compared to the LGL group. Improvements waned during Maintenance. Home d...Continue Reading
References
Nov 1, 1991·The American Journal of Clinical Nutrition·T M WoleverR G Josse
Oct 1, 1995·The American Journal of Clinical Nutrition·K Foster-Powell, J B Miller
Jul 1, 1996·Preventive Medicine·L S WebberR V Luepker
Jun 6, 2000·The American Journal of Clinical Nutrition·S LiuJ E Manson
Sep 12, 2000·Archives of Pediatrics & Adolescent Medicine·L E SpiethD S Ludwig
Mar 10, 2001·The American Journal of Clinical Nutrition·S LiuW C Willett
Jan 5, 2002·The American Journal of Clinical Nutrition·Sally D PoppittNicholas J Wareham
May 4, 2002·JAMA : the Journal of the American Medical Association·David S Ludwig
May 15, 2002·Obesity Research·Joey C EisenmannMin Qi Wang
Feb 11, 2003·The British Journal of Nutrition·Audrey E BrynesGary S Frost
Aug 13, 2003·Archives of Pediatrics & Adolescent Medicine·Cara B EbbelingDavid S Ludwig
Sep 2, 2003·The Journal of Nutrition·J C Brand-MillerS Colagiuri
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Kelly A MecklingDayna Saari
Jul 28, 2004·Diabetes Care·Salwa W RizkallaGerard Slama
May 11, 2005·The American Journal of Clinical Nutrition·Cara B EbbelingDavid S Ludwig
May 18, 2007·JAMA : the Journal of the American Medical Association·Cara B EbbelingDavid S Ludwig
Aug 3, 2007·Pediatrics·John A MorrisonCourtney Gray-McGuire
Jan 22, 2008·The Journal of Pediatrics·Terry T-K HuangJohn A Morrison
Feb 9, 2008·The American Journal of Clinical Nutrition·Jean-Philippe ChaputDavid S Ludwig
Mar 11, 2008·The American Journal of Clinical Nutrition·Alan W BarclayJennie C Brand-Miller
Jul 4, 2008·Pediatrics·Stephen R DanielsUNKNOWN Committee on Nutrition
May 28, 2009·Circulation·Elaine M UrbinaLawrence M Dolan
Jan 20, 2010·Pediatrics·Evelyn P WhitlockKevin W Lutz
Feb 12, 2010·The New England Journal of Medicine·Paul W FranksHelen C Looker
Nov 16, 2011·Pediatrics·UNKNOWN Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents, UNKNOWN National Heart, Lung, and Blood Institute
Jan 5, 2012·JAMA : the Journal of the American Medical Association·David S Ludwig
Jan 19, 2012·JAMA : the Journal of the American Medical Association·Cynthia L OgdenKatherine M Flegal
Mar 3, 2012·The Journal of Pediatrics·Shelley KirkStephen R Daniels
Oct 30, 2012·Journal of the Academy of Nutrition and Dietetics·Chii-Shy LinBarbara E Millen
Nov 21, 2012·Pediatrics·Mandy HoClare Collins
Dec 21, 2012·The American Journal of Clinical Nutrition·Nazrat M MirzaJack A Yanovski
Oct 22, 2013·Journal of the Academy of Nutrition and Dietetics·Lukas Schwingshackl, Georg Hoffmann
Apr 12, 2014·Annals of Internal Medicine·Rajiv ChowdhuryEmanuele Di Angelantonio
May 3, 2014·The American Journal of Clinical Nutrition·Martí Juanola-FalgaronaMònica Bulló
May 3, 2014·The American Journal of Clinical Nutrition·Shilpa N BhupathirajuFrank B Hu
Aug 6, 2014·Current Atherosclerosis Reports·Gareth R DuttonMichael G Perri
Citations
Dec 20, 2018·Circulation·Scott M GrundyJoseph Yeboah
Dec 28, 2018·Circulation·Scott M GrundyJoseph Yeboah
May 4, 2020·Advances in Nutrition·Barbara J DealNeil J Stone
Feb 26, 2019·Circulation·Sarah D de FerrantiAli N Zaidi
Jan 8, 2020·Journal of Obesity & Metabolic Syndrome·Jieun Kim, Hyunjung Lim
Nov 22, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M I ZafarL L Chen
Dec 8, 2020·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·K DuncansonC E Collins