Provisional Guideline Recommendation for EGFR Gene Mutation Testing in Liquid Samples of Lung Cancer Patients: A Proposal by the Korean Cardiopulmonary Pathology Study Group

Journal of Pathology and Translational Medicine
Dong Hoon ShinSe Jin Jang

Abstract

Liquid biopsy for detection of mutation from circulating tumor DNA is a new technology which is attractive in that it is non-invasive. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) is an effective first line drug for advanced non-small cell lung cancer patients who harbor activating EGFR mutation. During the course of treatment, resistance against TKI arises which can be contributed to EGFR T790M mutation in about 50-60% of patients. Third generation TKI may overcome the resistance. In patients who cannot undergo tissue biopsy due to variable reasons, liquid biopsy is an excellent alternative for the detection of EGFR T790M mutation. However, this relatively novel method requires standardization and vigorous quality insurance. Thus, a standard set of guideline recommendations for liquid biopsy for EGFR mutation testing suitable for the Korean medical community is necessary. In this article, we propose a set of provisional guideline recommendations that was discussed and approved by the Cardiopulmonary Pathology Study Group of the Korean Society of Pathologists.

References

Nov 7, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marissa N BalakWilliam Pao
Aug 2, 2008·Nature Medicine·Frank DiehlLuis A Diaz
Aug 21, 2009·The New England Journal of Medicine·Tony S MokMasahiro Fukuoka
Mar 25, 2011·Science Translational Medicine·Lecia V SequistJeffrey A Engelman
Aug 25, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Michael FleischhackerStefan Holdenrieder
Mar 9, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Helena A YuGregory J Riely
Oct 24, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mantang QiuRong Yin
Apr 4, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ying WuYong Song
Oct 24, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kenneth S ThressJ Carl Barrett
May 20, 2016·Archives of Pathology & Laboratory Medicine·Lynette M ShollYasushi Yatabe
Jun 30, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Geoffrey R OxnardPasi A Jänne
Jul 21, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Peter BallardDarren Cross
Jul 30, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Martin ReckNicola Normanno
Sep 24, 2016·Translational Lung Cancer Research·Mari Mino-Kenudson
Sep 24, 2016·Translational Lung Cancer Research·Marius Ilié, Paul Hofman
Nov 21, 2016·The Journal of Molecular Diagnostics : JMD·Laure SorberPatrick Pauwels
Feb 22, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James Chih-Hsin YangPasi A Jänne
Feb 25, 2017·Nature Reviews. Cancer·Jonathan C M WanNitzan Rosenfeld
Jun 14, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Reyes BernabéFiona Helen Blackhall
Aug 26, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Verena HaselmannMichael Neumaier

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Citations

May 29, 2020·Journal of Pathology and Translational Medicine·Sunhee ChangWan Seop Kim
May 11, 2021·Journal of Pathology and Translational Medicine·Sunhee ChangUNKNOWN Korean Cardiopulmonary Pathology Study Group

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Methods Mentioned

BETA
biopsy
PCR

Software Mentioned

ASSESS

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