PMID: 686877Aug 1, 1978Paper

Provocative agents and the diagnosis of medullary carcinoma of the thyroid gland

Annals of Surgery
S A WellsC W Cooper


Twenty-six patients with known or suspected medullary thyroid carcinoma (MTC) and 21 normal control subjects were tested intravenously on four separate days with calcium gluconate (CG), 2 mg Ca(++)/kg/1 min.; pentagastrin (P), 0.5 ug/kg/ 5 sec.; calcium chloride (CC), 3 mg Ca(++)/kg/10 min.; and a combination of calcium gluconate and pentagastrin (CG + P). Calcitonin (CT) levels were determined by radioimmunoassay on plasma collected before and immediately following each test infusion. In none of the 21 control subjects was there a clear increase in CT above 200 pg/ml following any of the four provocative tests. Conversely, in all 26 patients with known or suspected MTC, plasma CT levels were markedly increased (>300 pg/ml) following the combined infusion of CG + P. The peak CT response was greater with CG + P than with a) CG alone (22 of 24 patients, p < 0.002), b) P alone (25 of 26 patients, p < 0.002), or c) CC alone (17 of 17 patients, p < 0.002). Of 12 MTC patients with undetectable basal calcitonin levels, all had peak responses greater than 300 pg/ml following CG + P, whereas such responses occurred less often following CG alone (8 of 12) or P alone (8 of 12). The results demonstrate that the combined administration of p...Continue Reading


Jul 1, 1974·The Journal of Clinical Endocrinology and Metabolism·J G ParthemoreL J Deftos

❮ Previous
Next ❯


Mar 1, 1991·Seminars in Surgical Oncology·T C Lairmore, S A Wells
Oct 1, 1988·World Journal of Surgery·S JanssonG Stenström
Jan 1, 1983·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·M EricssonS Ingemansson
Oct 1, 1995·Trends in Endocrinology and Metabolism : TEM·D L LearoydB G Robinson
Sep 1, 1987·Journal of Pediatric Surgery·D P Girvan, R L Holliday
Feb 1, 1983·The Journal of Pediatrics·B A Jones, J C Sisson
Aug 30, 2003·Surgical Oncology·Michael A Skinner
Dec 17, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Giuseppe CostanteSebastiano Filetti
Jul 29, 1998·Journal of Internal Medicine·J F MoleyS A Wells
Aug 2, 1979·The New England Journal of Medicine·D L TrumpS B Baylin
Jan 29, 1981·The New England Journal of Medicine·L A Austin, H Heath
Jun 4, 1981·The New England Journal of Medicine·D Drucker
Sep 16, 2005·The New England Journal of Medicine·Michael A SkinnerSamuel A Wells
Oct 1, 1995·Thyroid : Official Journal of the American Thyroid Association·D J MarshB G Robinson
May 28, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association Guidelines Task ForceSamuel A Wells
May 1, 1983·Annals of Surgery·M E RomanusS A Wells
Jun 1, 1997·Annals of Surgery·J F MoleyM K DeBenedetti
Oct 14, 2006·Annual Review of Medicine·Vipul T LakhaniSamuel A Wells
Feb 1, 1981·American Journal of Ophthalmology·B SpectorS A Wells
Jan 12, 2008·World Journal of Surgery·Elizabeth FialkowskiJeffrey Moley
Jan 1, 1983·Critical Reviews in Clinical Laboratory Sciences·T D Trainer, P L Howard
Oct 1, 1996·Annals of Medicine·T C LairmoreS A Wells
Aug 21, 2013·Head & Neck·Pierpaolo TrimboliEnrico Papini
Mar 1, 1988·The American Journal of Medicine·R E SchoenH Shamoon
Jan 1, 1996·Journal of Pediatric Surgery·M A SkinnerS A Wells
Apr 6, 2001·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A F CarliA Neri
Sep 11, 1990·Journal of Pediatric Surgery·R A DeckerS A Wells
Jul 1, 1990·Trends in Endocrinology and Metabolism : TEM·W B Carter, H Heath
Apr 1, 1980·American Journal of Surgery·R L RossiJ Werber
May 1, 1985·Current Problems in Surgery·W G Cance, S A Wells

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.