PMID: 686877Aug 1, 1978Paper

Provocative agents and the diagnosis of medullary carcinoma of the thyroid gland

Annals of Surgery
S A WellsC W Cooper

Abstract

Twenty-six patients with known or suspected medullary thyroid carcinoma (MTC) and 21 normal control subjects were tested intravenously on four separate days with calcium gluconate (CG), 2 mg Ca(++)/kg/1 min.; pentagastrin (P), 0.5 ug/kg/ 5 sec.; calcium chloride (CC), 3 mg Ca(++)/kg/10 min.; and a combination of calcium gluconate and pentagastrin (CG + P). Calcitonin (CT) levels were determined by radioimmunoassay on plasma collected before and immediately following each test infusion. In none of the 21 control subjects was there a clear increase in CT above 200 pg/ml following any of the four provocative tests. Conversely, in all 26 patients with known or suspected MTC, plasma CT levels were markedly increased (>300 pg/ml) following the combined infusion of CG + P. The peak CT response was greater with CG + P than with a) CG alone (22 of 24 patients, p < 0.002), b) P alone (25 of 26 patients, p < 0.002), or c) CC alone (17 of 17 patients, p < 0.002). Of 12 MTC patients with undetectable basal calcitonin levels, all had peak responses greater than 300 pg/ml following CG + P, whereas such responses occurred less often following CG alone (8 of 12) or P alone (8 of 12). The results demonstrate that the combined administration of p...Continue Reading

References

Jul 1, 1974·The Journal of Clinical Endocrinology and Metabolism·J G ParthemoreL J Deftos

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Citations

Mar 1, 1991·Seminars in Surgical Oncology·T C Lairmore, S A Wells
Oct 1, 1988·World Journal of Surgery·S JanssonG Stenström
Jan 1, 1983·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·M EricssonS Ingemansson
Oct 1, 1995·Trends in Endocrinology and Metabolism : TEM·D L LearoydB G Robinson
Sep 1, 1987·Journal of Pediatric Surgery·D P Girvan, R L Holliday
Feb 1, 1983·The Journal of Pediatrics·B A Jones, J C Sisson
Aug 30, 2003·Surgical Oncology·Michael A Skinner
Dec 17, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Giuseppe CostanteSebastiano Filetti
Jul 29, 1998·Journal of Internal Medicine·J F MoleyS A Wells
Aug 2, 1979·The New England Journal of Medicine·D L TrumpS B Baylin
Jan 29, 1981·The New England Journal of Medicine·L A Austin, H Heath
Jun 4, 1981·The New England Journal of Medicine·D Drucker
Sep 16, 2005·The New England Journal of Medicine·Michael A SkinnerSamuel A Wells
Oct 1, 1995·Thyroid : Official Journal of the American Thyroid Association·D J MarshB G Robinson
May 28, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association Guidelines Task ForceSamuel A Wells
May 1, 1983·Annals of Surgery·M E RomanusS A Wells
Jun 1, 1997·Annals of Surgery·J F MoleyM K DeBenedetti
Oct 14, 2006·Annual Review of Medicine·Vipul T LakhaniSamuel A Wells
Feb 1, 1981·American Journal of Ophthalmology·B SpectorS A Wells
Jan 12, 2008·World Journal of Surgery·Elizabeth FialkowskiJeffrey Moley
Jan 1, 1983·Critical Reviews in Clinical Laboratory Sciences·T D Trainer, P L Howard
Oct 1, 1996·Annals of Medicine·T C LairmoreS A Wells
Aug 21, 2013·Head & Neck·Pierpaolo TrimboliEnrico Papini
Mar 1, 1988·The American Journal of Medicine·R E SchoenH Shamoon
Jan 1, 1996·Journal of Pediatric Surgery·M A SkinnerS A Wells
Apr 6, 2001·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A F CarliA Neri
Sep 11, 1990·Journal of Pediatric Surgery·R A DeckerS A Wells
Jul 1, 1990·Trends in Endocrinology and Metabolism : TEM·W B Carter, H Heath
Apr 1, 1980·American Journal of Surgery·R L RossiJ Werber
May 1, 1985·Current Problems in Surgery·W G Cance, S A Wells

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