Prox1 induces new lymphatic vessel formation and promotes nerve reconstruction in a mouse model of sciatic nerve crush injury.

Journal of Anatomy
Fan-Wei MengFang-Fang Shen

Abstract

The peripheral nervous system lacks lymphatic vessels and is protected by the blood-nerve barrier, which prevents lymphocytes and antibodies from entering the neural parenchyma. Peripheral nerve injury results in degeneration of the distal nerve and myelin degeneration causes macrophage aggregation, T lymphocyte infiltration, major histocompatibility complex class II antigen expression, and immunoglobulin G deposition in the nerve membrane, which together result in nerve edema and therefore affect nerve regeneration. In the present paper, we show myelin expression was absent from the sciatic nerve at 7 days after injury, and the expression levels of lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) and Prospero Homeobox 1 (Prox1) were significantly increased in the sciatic nerve at 7 days after injury. The lymphatic vessels were distributed around the myelin sheath and co-localized with lymphatic endothelial cells. Prox1 induces the formation of new lymphatic vessels, which play important roles in the elimination of tissue edema as well as in morphological and functional restoration of the damaged nerve. This study provides evidence of the involvement of new lymphatic vessels in nerve repair after sciatic nerve injury.

References

Nov 1, 1991·Journal of Neuropathology and Experimental Neurology·T W BouldinN D Goines
Aug 1, 1980·Journal of Neurology, Neurosurgery, and Psychiatry·B RydevikG Lundborg
Feb 20, 1999·Journal of Reconstructive Microsurgery·W AzizW C Breidenbach
Feb 20, 2002·Trends in Neurosciences·Hugh WillisonHans-Peter Hartung
Apr 3, 2002·The EMBO Journal·Jeffrey T WigleGuillermo Oliver
Apr 10, 2002·Journal of the Peripheral Nervous System : JPNS·Guido StollRobert R Myers
Nov 2, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Young-Kwon HongGuillermo Oliver
Apr 2, 2004·The Journal of Clinical Investigation·Claus CursiefenJ Wayne Streilein
Mar 8, 2005·Nature Immunology·Thomas JamiesonGerard J Graham
May 25, 2007·Nature Reviews. Molecular Cell Biology·Ralf H Adams, Kari Alitalo
Jul 24, 2007·Progress in Neurobiology·X NavarroAntoni Valero-Cabré
Nov 21, 2007·The Journal of Experimental Medicine·Matthias NahrendorfMikael J Pittet
Jun 4, 2008·Annals of the New York Academy of Sciences·William S Shin, Stanley G Rockson
Feb 25, 2010·Cell·Tuomas Tammela, Kari Alitalo
Sep 22, 2012·TheScientificWorldJournal·Carlos Rodrigo Camara-LemarroyNancy Esthela Fernandez-Garza
May 25, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H S GoedeeL H Visser
Jun 15, 2013·Cytokine·Melissa B Aldrich, Eva M Sevick-Muraca
Dec 30, 2014·Angiogenesis·Virginie BarbayEbba Brakenhielm
Sep 9, 2015·Investigative Ophthalmology & Visual Science·Chang Rae RhoChoun-Ki Joo
May 20, 2016·Rehabilitation Research and Practice·Jinzhuang XiaoXincai Yang
Jan 16, 2018·Somatosensory & Motor Research·Ramazan ÜstünAhmet Regaip Oğuz
Dec 12, 2018·Neural Regeneration Research·Martial CaillaudFabrice Billet

❮ Previous
Next ❯

Citations

Jul 30, 2021·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Isabel ZucalFlorian S Frueh
Nov 4, 2021·Proceedings of the National Academy of Sciences of the United States of America·Aravinthan VaratharajIan Galea

❮ Previous
Next ❯

Software Mentioned

SPSS
Image
Pro Plus

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

© 2022 Meta ULC. All rights reserved