Proximal colon distension induces Fos expression in the brain and inhibits gastric emptying through capsaicin-sensitive pathways in conscious rats

Brain Research
V MartínezY Taché

Abstract

We assessed brain nuclei activated during noxious mechanical distension of the proximal colon in conscious rats, using Fos as a marker of neuronal activation, and functional reflex changes in gastric emptying associated to colon distension. The role of capsaicin-sensitive afferents in Fos and gastric responses to distension was also investigated. Compared with sham distension, isovolumetric phasic distension of the proximal colon (10 ml, 30 s on/off for 10 min) increased significantly Fos expression 1 h after distension in selective brain areas, most prominently, the paraventricular and supraoptic nuclei of the hypothalamus (13-fold and 80-fold, respectively), the locus coeruleus-Barrington's nucleus complex (2-fold), area postrema (7-fold) and the nucleus tractus solitarius (4-fold). Increased Fos expression was also observed in the cingulate cortex, posterior paraventricular nucleus of the thalamus, periaqueductal gray and ventrolateral medulla. Distension of the proximal colon significantly inhibited gastric emptying by 82% and 34%, as measured 30 and 60 min after the distension respectively, compared with control. Pretreatment with systemic capsaicin prevented both the brain increase in Fos expression and the inhibition of ...Continue Reading

References

Jan 1, 1992·Scandinavian Journal of Gastroenterology·H J van WijkO J ten Thije
Apr 1, 1992·Journal of the Autonomic Nervous System·L Bojö, J Cassuto
May 1, 1990·Pain·T J Ness, G F Gebhart
Sep 1, 1989·Journal of Neuroscience Methods·M Dragunow, R Faull
Oct 1, 1984·Digestive Diseases and Sciences·M S Youle, N W Read
Sep 22, 1980·Brain Research·C B Saper, A D Loewy
Jan 1, 1995·Clinical and Experimental Hypertension : CHE·Z J GierobaW W Blessing
Nov 8, 1994·The Journal of Comparative Neurology·B BonazY Taché
Jan 2, 1995·The Journal of Comparative Neurology·R K ChanP E Sawchenko
Jul 1, 1994·Digestive Diseases and Sciences·J ZighelboimS F Phillips
Jan 20, 1998·Brain Research Bulletin·J A Harris
Jun 15, 1999·Trends in Pharmacological Sciences·R J ValentinoL A Pavcovich
Apr 20, 2000·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B BonazC Feuerstein
Nov 7, 2000·The Journal of Comparative Neurology·K Van PettP E Sawchenko
Feb 24, 2001·Autonomic Neuroscience : Basic & Clinical·H R Berthoud, W L Neuhuber
Feb 22, 2002·Experimental Physiology·Caroline Gauriau, Jean-François Bernard
Nov 28, 2002·Gastroenterology·Douglas A DrossmanWilliam E Whitehead
Dec 19, 2003·The Journal of Comparative Neurology·Luc JasminPeter T Ohara
Dec 23, 2003·The European Journal of Neuroscience·Marie-Laure Rouzade-DominguezRita J Valentino
Mar 17, 2004·Neuroscience and Biobehavioral Reviews·G F Gebhart
May 11, 2005·Neuroscience Letters·R P J de LangeR Stam
Aug 5, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J LazovicA Ouyang

❮ Previous
Next ❯

Citations

May 2, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Muriel LaraucheYvette Taché
Jun 9, 2012·BMC Neuroscience·Dave J Hayes, Georg Northoff
Aug 24, 2011·Journal of Neurogastroenterology and Motility·Muriel LaraucheYvette Taché
Apr 16, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Chun-Yen ChenChi-Hsien Chien
Mar 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Chun-Yen ChenChi-Hsien Chien
Mar 25, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A Ait-BelgnaouiV Theodorou
Aug 29, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L HultinE Lindström
Jan 18, 2015·European Journal of Pharmacology·Sergey S PanteleevOlga А Lyubashina
Jun 14, 2016·Neuromodulation : Journal of the International Neuromodulation Society·Yee Ian YikBridget R Southwell
Aug 11, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mu LinJianhui Zhong
Feb 12, 2011·Expert Review of Gastroenterology & Hepatology·Daniel P HolschneiderEmeran A Mayer
Nov 27, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sylvie BradesiEmeran A Mayer
Mar 3, 2007·Biological & Pharmaceutical Bulletin·Tohru Komada, Shingo Yano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.