Proximal hypospadias and risk of acquired cryptorchidism

The Journal of Urology
Gregory E TasianL S Baskin

Abstract

We hypothesized that boys with proximal hypospadias are at increased risk for acquired cryptorchidism. We retrospectively studied the records of 114 boys who underwent repair for proximal hypospadias and had at least 1 year of followup, and 342 age matched boys receiving well child examinations. We used chi-square analysis to determine if cryptorchidism prevalence differed between the cohorts. Association between predictor (presence and severity of hypospadias, ethnicity/race, age, medical comorbidities) and outcome (acquired cryptorchidism, primary cryptorchidism, retractile testes) variables was modeled using univariate analysis and multivariate logistic regression. A total of 22 subjects (19%) with hypospadias had 26 nonscrotal testes, of which 2 (2%) represented primary cryptorchidism, 16 (14%) acquired cryptorchidism and 8 (7%) retractile testes. A total of 12 controls (3.5%) had 15 nonscrotal testes, of which 6 (1.8%) represented primary cryptorchidism, 1 (0.3%) acquired cryptorchidism and 8 (2.3%) retractile testes. Children with hypospadias had a higher prevalence of acquired cryptorchidism and retractile testes (all p <0.05). Hypospadias (OR 60.67, 95% CI 7.79-472.80) and increasing age (OR 1.02, 95% CI 1-1.03) were as...Continue Reading

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Citations

Jun 3, 2011·Journal of Perinatal Medicine·Stefan F NemecDaniela Prayer
Apr 30, 2011·The Journal of Urology·Toshihiko ItesakoKenji Shimada
Jun 10, 2011·International Journal of Andrology·W W M HackR W Meijer
Jan 1, 2012·Clinical Pediatric Endocrinology : Case Reports and Clinical Investigations : Official Journal of the Japanese Society for Pediatric Endocrinology·Fumi MatsumotoShinobu Ida
Feb 15, 2012·Orvosi hetilap·László SágodiJudit Kovács
May 27, 2014·The Journal of Urology·Thomas F KolonJulia S Barthold
Aug 12, 2014·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Manuel NistalMiguel Reyes-Múgica
Jan 28, 2014·Korean journal of urology·Hyunsoo AhnHwang Choi
May 15, 2013·Endocrine Reviews·John M HutsonNan Chen
Aug 10, 2019·Frontiers in Endocrinology·Tanja Kuiri-HänninenUlla Sankilampi

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