Proximal to middle left coronary artery flow velocity ratio, as assessed using color Doppler echocardiography, predicts coronary artery atherosclerosis in mice

Arteriosclerosis, Thrombosis, and Vascular Biology
Julia GrönrosLi-ming Gan

Abstract

We aimed to establish a completely noninvasive technique to assess coronary artery atherosclerosis in living mice using proximal to middle left coronary artery (LCA) velocity ratio as assessed with color Doppler echocardiography (CDE). Three groups of apolipoprotein E/low-density lipoprotein receptor double-knockout (apoE/LDLr dko) mice 10, 40, and 80 weeks of age and 3 additional age-matched groups of C57BL/6 mice were examined under anesthesia. Coronary flow velocity in proximal (Vprox) and middle part (Vmid) of LCA was measured using CDE. A 40-MHz ultrasound biomicroscope (UBM) was used to visualize lumen and outer vessel diameter in the proximal LCA. Flow velocity in the proximal LCA increased significantly with age and remained constant in the middle part in the apoE/LDLr dko mice, whereas velocities at both the sites remained unchanged in C57 mice. CDE-assessed flow velocity ratio (Vprox/Vmid) increased significantly with age in apoE/LDLr dko mice (P=0.0055) and correlated significantly to percentage wall thickness, as assessed by UBM (P=0.0044; r=0.65) and histology (P=0.0002; r=0.78). Wall thickness increased with age in the apoE/LDLr dko mice as measured with UBM (P=0.0093; r=0.49), which was also confirmed with histol...Continue Reading

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Citations

Oct 25, 2011·Pflügers Archiv : European journal of physiology·Lei YingYuansheng Gao
Jul 24, 2013·Journal of Cardiovascular Translational Research·Li-Ming GanRegina Fritsche-Danielson
May 17, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Craig J HartleyGeorge E Taffet
Mar 4, 2018·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Fabiana BlancoMaria F Gomez
Apr 25, 2007·NMR in Biomedicine·Nicolau BeckmannMatthias Müller
Oct 23, 2014·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Sauli UotilaAntti Saraste

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