Proximal tubular angiotensinogen in renal biopsy suggests nondipper BP rhythm accompanied by enhanced tubular sodium reabsorption

Journal of Hypertension
Michio FukudaHiroyuki Kobori

Abstract

The renal capacity for sodium excretion is impaired by a reduction in the glomerular ultrafiltration coefficient and by enhancement of the fractional tubular sodium reabsorption (FRNa), leading to a nondipper circadian blood pressure (BP) rhythm. Angiotensin II in the systemic circulation can be easily filtered across the glomerular capillary walls and stimulates renal proximal tubular angiotensinogen (PT-AGT) production, leading to the activation of intrarenal angiotensin II, which is known to augment the FRNa in animal models. We performed an immunohistochemical investigation to determine the contribution of PT-AGT to enhancement of FRNa and the nondipper circadian BP rhythm in 40 consecutive patients with primary IgA nephropathy (IgAN). Immunostaining for PT-AGT was increased in the IgAN patients compared with control individuals (P = 0.04), and correlated directly with the FRNa (r = 0.39, P = 0.01) and the night/day ratio of BP (r = 0.38, P = 0.02), but not creatinine clearance (r = -0.008, P = 0.9). The night/day ratio of BP was determined by both creatinine clearance (r = -0.36, P = 0.03) and FRNa (r = 0.47, P = 0.006). Tubular sodium reabsorption is stimulated by intrarenal angiotensin II, as indicated by PT-AGT, and con...Continue Reading

References

Aug 1, 1991·Circulation Research·G KimuraM Kawamura
Aug 13, 1988·Lancet·E O'BrienK O'Malley
Jan 1, 1971·Cardiovascular Research·A B Gould, D Green
Feb 1, 1984·The Journal of Clinical Investigation·V L SchusterH R Jacobson
May 20, 1999·Journal of Human Hypertension·S KurodaG Kimura
Apr 19, 2002·Journal of the American Society of Nephrology : JASN·János Peti-PeterdiP Darwin Bell
Sep 13, 2002·The New England Journal of Medicine·Empar LurbeDaniel Batlle
Jun 9, 2006·Medical Hypotheses·Michio FukudaGenjiro Kimura
May 8, 2007·Biochemical and Biophysical Research Communications·Hiroyuki KoboriTatsuya Shoji
Jul 3, 2009·Kidney International·UNKNOWN Working Group of the International IgA Nephropathy Network and the Renal Pathology SocietyHong Zhang
Mar 11, 2011·The New England Journal of Medicine·Hermann HallerUNKNOWN ROADMAP Trial Investigators
Aug 26, 2011·American Journal of Physiology. Renal Physiology·Michio FukudaGenjiro Kimura

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Citations

Aug 25, 2012·Pflügers Archiv : European journal of physiology·Hiroyuki Kobori, Maki Urushihara
Jun 2, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jolanta SoltysiakJacek Zachwieja
Jan 8, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shinsuke IsobeHideo Yasuda
Apr 15, 2016·Sleep Medicine Reviews·Michael H SmolenskyFrancesco Portaluppi
Nov 8, 2012·Chronobiology International·Michio FukudaGenjiro Kimura
Dec 20, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Maki UrushiharaShoji Kagami
Apr 15, 2014·Clinical and Experimental Nephrology·Shinsuke IsobeYoshihide Fujigaki
Jul 6, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Maki Urushihara, Shoji Kagami
Dec 3, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Naro OhashiHideo Yasuda
Dec 3, 2016·Internal Medicine·Naro OhashiHideo Yasuda
Mar 7, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Naro OhashiHideo Yasuda
Jan 24, 2018·American Journal of Physiology. Renal Physiology·Dingguo Zhang, David M Pollock
Nov 2, 2016·International Journal of Molecular Sciences·Tomoko MizushigeAkira Nishiyama
Jul 23, 2016·Clinical and Experimental Nephrology·Michio FukudaNobuyuki Ohte
Jan 3, 2021·Medical Hypotheses·Merve MercanNurettin Abacıoğlu

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