Abstract
Renal plasma flow (RPF) and glomerular filtration rate (GFR) were measured during waterloading and constant infusion of [131I]hippuran and [125I]iothalamate in 24 mild to moderate essential hypertensive patients before and after 3.5 months treatment with atenolol. Clearances of sodium and potassium were measured 2-3 hours post-dosing and renal vascular resistance (RVR) and filtration fraction (FF) were calculated. Measurement of clearance of lithium (CLi) and uric acid (Curic acid) was employed to investigate specifically proximal tubular function. Beta-blockade with atenolol produced a borderline significant decrement in RPF but no change in GFR, RVR and FF. There was a significant reduction in CLi, fractional proximal escape of sodium and water, Curic acid and an increase in absolute proximal reabsorption of sodium, indicating an inhibition of proximal tubular function. The distal tubular parameters exhibited changes tending to normalize excretion of sodium, but not water. Changes in RVR were inversely related to changes in CLi and Curic acid, suggesting unopposed alfa-adrenergic stimulation to be implicated in the renal counterregulation at a proximal tubular site following long-term administration of atenolol in essential h...Continue Reading
References
Sep 1, 1979·Clinical Pharmacology and Therapeutics·O L Pedersen, E Mikkelsen
Nov 1, 1975·Acta Medica Scandinavica·E B Pedersen
Sep 1, 1992·Journal of Cardiovascular Pharmacology·L R KrusellO L Pedersen
Jan 1, 1985·European Journal of Clinical Pharmacology·O L PedersenK Stengaard-Pedersen
Jan 1, 1986·European Journal of Clinical Pharmacology·L R KrusellO Lederballe Pedersen
Aug 1, 1987·Hypertension·H NakaokaT Yamaji
May 1, 1987·Pharmacopsychiatry·M Schou, P Vestergaard
Jan 1, 1971·The Journal of Clinical Investigation·J R Gill, A G Casper
Oct 1, 1972·Clinical Science·L M BlendisN G Levinsky
Sep 1, 1971·Scandinavian Journal of Clinical and Laboratory Investigation·C E Mogensen
Oct 1, 1971·Circulation·A S NiesR W Schrier
Feb 1, 1969·Canadian Journal of Physiology and Pharmacology·S Carrière
Nov 1, 1980·Kidney International·M A Weber, J I Drayer
Jan 1, 1982·Hypertension·P W de Leeuw, W H Birkenhäger
Jan 1, 1984·Nephron·K Thomsen
Mar 1, 1993·Blood Pressure·L R KrusellO L Pedersen
Feb 1, 1993·Cardiovascular Drugs and Therapy·H E BøtkerE V Sørensen
Citations
Jan 17, 2002·Journal of Clinical Laboratory Analysis·B K FleschJ Neppert
Jul 15, 2005·Kidney International·Grégoire WuerznerMichel Burnier
Jan 8, 2010·International Journal of Cardiology·Chung-Sheng LinChin-Hsung Huang
Jun 17, 2003·Journal of Cardiovascular Pharmacology and Therapeutics·Evangelos RizosD P Mikhailidis
Jul 11, 2001·Journal of Cardiovascular Pharmacology·C Delles, R E Schmieder
Dec 26, 2001·Chemical Reviews·N J Birch
Nov 21, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·T C DowlingM A Zemaitis